%0 Journal Article
%T Novel Histological Evidence of Collagen and Elastin Regeneration in Fractional RF-Treated Acne Scars
%A Judith Hellman
%A Jonathan Yao
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 155-164
%@ 2161-4512
%D 2019
%I Scientific Research Publishing
%R 10.4236/jcdsa.2019.92013
%X <strong>Introduction:</strong> Fractional radiofrequency (RF) technology has been shown to be a gold standard therapy for acne scars. We have previously published clinical and histological results from the treatment of 8 patients with active acne and acne related scarring using a fractional RF device. Evidence of safety and efficacy was demonstrated, including long term follow-up clinical results from 4 patients, up to two years post last fractional treatment. In the current article we present histology evidence of acne scar skin renewal 3.5 years post treatment. <strong>Methods:</strong> Skin biopsies from acne scars in a concealed facial area were taken before, after four treatments and at 3.5 years after the last fractional treatment. Biopsies were examined with standard hematoxylin and eosin (H&amp;E) stain, as well as Verhoeff¡¯s Van Gieson (VVG) and Shikata stains for elastic fibers. <strong>Results:</strong> Histological findings demonstrate regeneration of elastic fibers and reduction of the dermal fibrosis. Scar depth of Patient #2 was reduced by 80% in the corresponding follow-up period. <strong>Conclusion:</strong> The long-term histological results further support the previously published findings that fractional RF is a safe and effective treatment for acne related scars.
%K Fractional Radiofrequency
%K Acne Scars
%K Histological Evidence
%K Long Term Follow-Up
%K Elastic Fibers Regeneration
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=92895