%0 Journal Article
%T Anti-Inflammatory Activity of Geldanamycin and Its Derivatives in LPS-Induced RAW 264.7 Cells
%A Thongchai Taechowisan
%A Winyou Puckdee
%A Watcharee Waratchareeyakul
%A Waya S. Phutdhawong
%J Advances in Microbiology
%P 398-421
%@ 2165-3410
%D 2019
%I Scientific Research Publishing
%R 10.4236/aim.2019.94024
%X Geldanamycin <b>(1)</b> had been isolated as a major compound from <i>Streptomyces zerumbet</i> W14; an endophyte of <i>Zingiber zerumbet</i> (L.) Smith. Two new geldanamycin derivatives; 17-(tryptamine)-17-demethoxygeldanamycin <b>(2)</b> and 17-(5¡¯-methoxytryptamine)-17-demethoxygeldanamycin <b>(3)</b> were synthe- sized and their anti-inflammatory activity was evaluated in LPS-induced macrophage RAW 264.7 cells by investigating their effects on the inhibition of production of NO, PGE<sub>2</sub>, TNF-<i>&#945;</i>, IL-1<i>&#946;</i>, IL-6 and IL-10. The data obtained were consistent with the modulation of TNF-¦Á, IL-1¦Â, IL-6, IL-10 production by these derivatives at concentration of 1 to 5 ¦Ìg/ml. A similar effect was also observed when LPS-induced NO release and PGE2 production were tested. The inhibitory effects were shown in concentration-dependent manners. From the obtained results, it was concluded that two new gelda- namycin derivatives possess anti-inflammatory activity on LPS-induced RAW 264.7 cells. They could be useful for the management of inflammatory diseases.
%K Anti-Inflammatory Activity
%K Geldanamycin Derivatives
%K &lt
%K i&gt
%K Streptomyces zerumbet&lt
%K /i&gt
%K RAW 264.7 Cells
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=92174