%0 Journal Article
%T 河南省2009至2014年疑似预防接种异常反应监测分析<br>Analysis on surveillance of suspected adverse events following immunization in Henan Province, 2009-2014
%A 叶
%A 莹
%A 史鲁斌
%A 李
%A 军
%A 姬艳芳
%A 于
%A 燕
%A 董蒲梅
%A 张延炀
%J 郑州大学学报（医学版）
%D 2016
%X 目的:分析河南省2009至2014年疑似预防接种异常反应(AEFI)的发生特征,评价疫苗安全性。方法:通过中国疾病预防控制信息系统AEFI信息管理系统,收集河南省2009至2014年报告的AEFI个案数据,采用描述流行病学方法进行分析。结果:河南省2009至2014年共收集AEFI个案13 282例,年均报告发生率为54.41/100万剂,其中严重AEFI 356例,报告发生率为1.46/100万剂。男女性别比为1.36？？GA6FA？？1; 2岁以下儿童占71.33%; 报告病例主要集中在洛阳、郑州和焦作等地。报告数最多的疫苗是吸附无细胞百白破疫苗(4 070例),报告发生率最高的是7价肺炎疫苗(790.00/100万剂),严重AEFI报告发生率最高的为麻疹疫苗(56.19/100万剂)。AEFI一般反应临床损害以发热、红肿、硬结为主,异常反应以过敏反应性疾病为主。所有AEFI中,治愈或好转占98.93%。60例死亡病例中,异常反应死亡18例。结论:较低的严重AEFI报告发生率和较好的预后提示河南省疫苗安全性良好。<br>Aim: To analyze the occurrence features of suspected adverse events following immunization(AEFI)in Henan Province,2009-2014, and to provide the basis for evaluation of vaccine safety.Methods: 2009-2014 AEFI data were collected through the Chinese Disease Prevention and Control Information System for AEFI information management system. The descriptive methodology was used in the study.Results: A total of 13 282 AEFI cases were reported in Henan Province 2009-2014,and the reported incidence rate was 54.41 per 1 000 000 doses, in which, 356 cases were serious AEFI and the reported incidence rate was 1.46 per 1 000 000 doses. The ratio of male to female was 1.36？？GA6FA？？1, cases<2 year old accounted for 71.33%, and the reported cases were mainly concentrated in Luoyang, Zhengzhou, and Jiaozuo. The largest number of cases of vaccine was Adsorbed Diphtheria, Tetanus and Acellular Pertusis Combined Vaccine(4 070 cases), the highest reported incidence rate of vaccine was 7 pneumococcal conjugate vaccine(790.00 per 1 000 000), and the highest reported incidence rate of serious AEFI was measles vaccine(56.19 per 1 000 000). The main symptoms of common vaccine reactions were fever, local swelling and indurations, the main diagnosis of rare vaccine reactions was anaphylactic disorders. Out of all AEFI cases, 98.93% were recovered or got better. In 60 death cases, 18 were rare vaccine reactions.Conclusion: Lower incidence rate of serious AEFI and better prognosis showed that vaccine safety is good in Henan Province
%K 疑似预防接种异常反应
%K 疫苗
%K 监测
%K 河南省&lt
%K br&gt
%K suspected adverse events following immunization
%K vaccine
%K surveillance
%K Henan Province
%U http://jms.zzu.edu.cn/oa/darticle.aspx?type=view&id=201602030