%0 Journal Article
%T CPAP治疗对2型糖尿病合并OSAHS患者糖尿病临床控制的作用<br>Effect of CPAP on clinical control of diabetes in patients with OSAHS and type 2 diabetes mellitus
%A 刘凯坤
%A 袁慧娟
%A 袁倩
%A 虎子颖
%A 史晓阳
%A 张会峰
%A 赵志刚
%J 郑州大学学报（医学版）
%D 2015
%X 要目的：评价持续气道正压通气（CPAP）治疗对2型糖尿病（T2DM）合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者糖尿病临床控制的作用。方法：收集T2DM合并OSAHS住院患者53例，给予动态血糖监测、多导睡眠图监测,53例接受短期CPAP治疗（持续1晚），17例接受长期CPAP治疗（3个月）；CPAP治疗前后测定空腹血糖、胰岛素、糖化血红蛋白（HbA1c），计算稳态模型胰岛素抵抗指数（HOMA？？IR）。另选取单纯T2DM患者30例，2组患者于确诊次日测定空腹及餐后1 h胰高血糖素？？1（GLP？？1），计算ΔGLP？？1。结果：T2DM合并OSAHS患者短期CPAP治疗后，夜间血糖、平均血糖波动幅度及HOMA？？IR均降低（t配对=2.800、3.132和4.344，P＜0.05）；长期CPAP治疗后，HbA1c与HOMA？？IR降低（t配对=3.733、3.329，P＜0.05）。T2DM合并OSAHS组患者ΔGLP？？1较单纯T2DM组患者降低（t=2.265，P=0.026）。结论：T2DM合并OSAHS患者CPAP治疗后糖尿病得到临床控制；OSAHS可能影响患者GLP？？1的分泌。<br>Aim: To explore the effect of continuous positive airway pressure(CPAP) treatment on clinical control of diabetes in patients with OSAHS and type 2 diabetes mellitus. Methods: Fifty？？three patients with OSAHS and type 2 diabetes mellitus were recruited,among whom,53 accepted short？？term CPAP treatment,and 17 accepted long？？term CPAP treatment. Continuous glucose monitoring system, polysomnographic monitoring and CPAP treatment were applied. Fasting glucose, insulin and HbA1c were measured before and after CPAP. Another 30 patients with type 2 diabetes mellitus were collected and the fasting GLP？？1 and 1 h postprandial GLP？？1 of the patients in the 2 groups were determined,and ΔGLP？？1 was calculated.Results: After short？？term CPAP treatment, nocturnal blood glucose, MAGE and HOMA？？IR in patients with OSAHS and type 2 diabetes mellitus were lower than those before treatment(tpaired=2.800,3.132 and 4.344，P＜0.05). After 3 month CPAP treatment, HbA1c and HOMA？？IR were lower than those before treatment(tpaired=3.733 and 3.329，P＜0.05). The ΔGLP？？1 in patients with OSAHS and type 2 diabetes mellitus was lower than that in patients with type 2 diabetes mellitus(t=2.265，P=0.026).Conclusion: After CPAP treatment, the diabetic indexes of patients with OSAHS and type 2 diabetes mellitus are under control and OSAHS may affect the secretion of GLP？？1
%K 糖尿病
%K 2型
%K 睡眠呼吸暂停
%K 阻塞性
%K 持续气道正压通气
%K 血糖&lt
%K br&gt
%K diabetes mellitus
%K type 2
%K sleep apnea
%K obstructive
%K continuous positive airway pressure
%K blood glucose
%U http://jms.zzu.edu.cn/oa/darticle.aspx?type=view&id=201504023