%0 Journal Article
%T CT引导下组织间植入125I粒子联合替吉奥治疗老年胰腺癌疗效分析<br>Efficacy of CT？？guided implantation of 125I seeds combined with S？？1 in treatment of pancreatic cancer in elderly patients
%A 李帅
%A 周志刚
%A 高剑波
%A 潘元威
%A 王猛
%J 郑州大学学报（医学版）
%D 2015
%X 目的：评价125I粒子组织间植入联合替吉奥胶囊化疗在治疗老年胰腺癌中的临床价值。方法：51例老年胰腺癌患者分为2组：观察组27例行125I粒子植入联合替吉奥胶囊化疗，对照组24例行替吉奥单药化疗；对比2组疗效、毒性反应及临床受益反应，并应用Kaplan？？Meier 法绘制生存曲线。结果：观察组有效率为70.4%，对照组为37.5%（χ2=5.545,P=0.019）；观察组疾病控制率为92.6%，对照组为62.5%（χ2=0.966,P=0.326）。观察组临床受益反应有效率为55.6%，对照组为25.0%（Z=2.476，P=0.013）。2组毒性反应发生率比较，差异无统计学意义(χ2=0.919,P=0.406)。观察组中位生存期为11.0（9.7~12.2）个月,6、12个月生存率分别为87.8%、27.7%；对照组分别为8.0（6.6~9.3）个月和67.8%、10.4%（Z=8.029,P=0.005）。结论：125I粒子组织间植入联合替吉奥化疗治疗老年胰腺癌临床疗效明确，可有效延长生存期。<br>Aim: To evaluate the clinical effect of 125I seeds implantation combined with chemotherapy of S？？1 in the treatment of pancreatic cancer in elderly patients.Methods: Clinical data of 51 pancreatic cancer patients were analyzed. The observation group(27 patients) were treated by CT？？guided 125I seed implantation combined with chemotherapy of S？？1.The control group(24 patients) were treated by chemotherapy of S？？1. The curative effect, toxic response and clinical benefit response were compared, survival curve was drown by Kaplan？？Meier method. Results: The effective rate of the observation group was 70.4%, and that of the control group was 37.5%（χ2=5.545,P=0.019）. The disease control rate of the observation group was 92.6%, and that of the control group was 62.5%（χ2=0.966,P=0.326）.The clinical benefit response rate of the observation group was 55.6%, and that of the control group was 25.0%（Z=2.476,P=0.013）.The toxic reaction between observation group and control group had no significant difference(χ2=0.919,P=0.406). The median survival time of the observation group was 11.0（9.7~12.2） months, the survival rates of 6 and 12 months were 87.8% and 27.7%, and those of the control group were 8.0(6.6~9.3) months, 67.8% and 10.4%（Z=8.029,P=0.005).Conclusion: 125I seeds implantation combined with chemotherapy of S？？1 in treatment of pancreatic cancer in elderly patients has an affirmative clinical efficacy and could effectively prolong survival
%K 老年胰腺癌
%K 125I粒子
%K 替吉奥&lt
%K br&gt
%K elderly pancreatic cancer
%K 125I seed
%K S？？1
%U http://jms.zzu.edu.cn/oa/darticle.aspx?type=view&id=201502033