%0 Journal Article %T 宫颈癌和宫颈上皮内瘤变组织中成纤维活化蛋白α的表达*<br>Expression of fibroblast activation protein α in cervical cancer and cervical intraepithelial neoplasia tissue %A 徐丽伟 %A 张梦真 %J 郑州大学学报(医学版) %D 2015 %X 目的:检测宫颈癌和宫颈上皮内瘤变(CIN)组织中成纤维活化蛋白α(FAPα)的表达情况。方法:采用免疫组化SP法检测10例宫颈炎、40例CIN及81例宫颈癌组织中FAPα的表达。结果:FAPα在宫颈炎组织中不表达,宫颈癌组织中FAPα阳性表达率高于CIN组织(χ2=81.706,P<0.001)。不同组织学类型(Z=2.069,P=0.039)、淋巴结转移情况(Z=3.382,P=0.001)和浸润深度(Z=2.185,P=0.029)的宫颈癌组织中FAPα表达水平比较,差异有统计学意义。结论:FAPα可能参与了宫颈癌的发生发展。<br>To detect the expression of fibroblast activation protein α (FAPα) in cervical cancer and cervical intraepithelial neoplasia tissue. Methods: FAPα expression in 10 cases of human cervicitis, 40 cases of cervical intraepithelial neoplasia and 81 cases of cervical cancer tissue was detected by SP method.Results: FAPα expression was higher in cervical cancer tissue than that in cervical intraepithelial neoplasia tissue(χ2 =81.706,P<0.001). FAPα expression in cervical cancer tissue was different with different histopathologic type(Z=2.069,P=0.039), lymph node metastasis(Z=3.382,P=0.001), and depth of invasion(Z=2.185,P=0.029).Conclusion: FAPα may take part in invasion and metastasis of cervical cancer %K 宫颈癌 %K 宫颈上皮内瘤变 %K 成纤维活化蛋白α %K 浸润 %K 转移< %K br> %K cervical cancer %K cervical intraepithelial neoplasia %K fibroblast activation protein α %K invasion %K metastasis %U http://jms.zzu.edu.cn/oa/darticle.aspx?type=view&id=201503018