%0 Journal Article
%T 髓样细胞触发受体-1在寻常型银屑病中的表达及意义<br>Expression of Trem-1 and its significance in psoriasis vulgaris
%A 涂
%A 晨
%A 王
%A 爽
%A 张
%A 扬
%A 任建文
%A 王晓鹏
%A 肖生祥
%J 西安交通大学学报(医学版)
%D 2016
%R 10.7652/jdyxb201603026
%X 摘要：目的 通过对比髓样细胞触发受体-1(Trem-1)在寻常型银屑病患者与正常人皮肤组织及血液中的表达差异，探索寻常型银屑病发病的可能机制。方法 采用免疫组化及实时荧光定量PCR的方法检测Trem-1在不同组织中的表达情况，应用SPSS21.0统计软件进行统计学分析。结果 Trem-1在寻常型银屑病患者皮损中表达增加，主要表达于表皮全层，正常皮肤组织中主要表达于基底细胞层，其表达差异具有统计学意义(P<0.05)。Trem-1 mRNA在寻常型银屑病皮损、血液中表达升高，与正常组相比差异具有统计学意义(P<0.05)；且Trem-1mRNA表达与银屑病皮损面积和严重程度指数(PASI)呈正相关(P<0.05)。结论 Trem-1的异常表达可能参与了寻常型银屑病发病，Trem-1可能成为治疗寻常型银屑病的潜在靶点。<br>ABSTRACT: Objective To study the expression of triggering receptor expressed on myeloid cells-1 (Trem-1) in psoriatic vulgaris and normal skin tissues and blood, and to explore the potential pathogenesis of psoriasis. Methods Immunohistochemistry and Real-time PCR were used to detect the expression of Trem-1 in the blood and tissues of normal skin and psoriasis. Results The positive expression rate of Trem-1 in psoriatic lesion was significantly higher than normal tissue. Trem-1 was expressed in the whole epidermis, with a significant difference (P<0.05). The mRNA expression of Trem-1 was significantly higher in psoriatic skin tissues and blood than in normal skin tissues and blood (P<0.05). Moreover, the mRNA expression of Trem-1 was positively correlated with PASI (P<0.05). Conclusion Abnormal expression of Trem-1 might be related to the pathogenesis of psoriasis. Trem-1 will cure psoriasis vulgaris as the potential therapeutic target
%K 髓样细胞触发受体-1
%K 寻常型银屑病
%K 免疫组化
%K 实时荧光定量PCR&lt
%K br&gt
%K triggering receptor expressed on myeloid cells-1 (Trem-1)
%K psoriasis vulgaris
%K immunohistochemistry
%K Real-time PCR
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201603026