%0 Journal Article
%T 辛伐他汀对食管癌细胞放疗敏感性的影响<br>Simvastatin enhances the radiosensitivity of esophageal squamous cell carcinoma
%A 金迎迎
%A 卫 阳
%A 王 力
%A 何 ？S
%A 贾 辉
%A 马红兵
%A 孙晓力
%J 西安交通大学学报(医学版)
%D 2016
%R 10.7652/jdyxb201604019
%X 摘要：目的 观察辛伐他汀对食管癌细胞放疗敏感性的影响。方法 应用间断照射的方法诱导食管癌细胞EC9706的放射抗拒细胞R-resistant；Cell Counting Kit-8检测辛伐他汀联合放疗对食管癌细胞EC9706及其放射抗拒细胞R-resistant增殖的影响；集落形成实验检测辛伐他汀对食管癌细胞EC9706及其放射抗拒细胞R-resistant的放疗敏感性的影响。结果 成功诱导出食管癌细胞EC9706的放射抗拒细胞R-resistant，Cell Counting Kit-8实验及集落形成实验结果都显示辛伐他汀可以增强食管癌细胞EC9706及其放射抗拒细胞R-resistant对放疗的敏感性。结论 辛伐他汀可以增强食管癌细胞的放疗敏感性。<br>ABSTRACT: Objective To study the effect of simvastatin on the radiosensitivity of esophageal squamous cell carcinoma. Methods Interrupted radiation was used to induce the radioresistance EC9706, named R-resistant cell. The effect of simvastatin on the proliferation and radiosensitivity of EC9706 and R-resistant cells were examined by Cell Counting Kit-8 assay and colony formation assay, respectively. Results The radioresistance EC9706, named R-resistant, was induced successfully. The results of Counting Kit-8 assay and colony formation assay indicated that simvastatin could sensitize EC9706 and the radioresistance of R-resistant to irradiation. Conclusion Simvastatin can sensitize esophageal squamous cell carcinoma to irradiation
%K 辛伐他汀
%K 食管癌
%K 放疗抗拒
%K 增敏&lt
%K br&gt
%K simvastatin
%K esophageal squamous cell carcinoma
%K radioresistance
%K sensitization
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201604019