%0 Journal Article
%T 围孕期妇女4种生活因素与新生儿先天性心脏病关系的广义线性模型分析<br>Generalized linear model analysis of the relationship of four kinds of prenatal lifestyle factors and congenital heart disease
%A 张
%A 若
%A 马
%A 慧
%A 闫
%A 慧
%A 王亚琴
%A 米
%A 阳
%A 陈方尧
%A 屈鹏飞
%A 李姗姗
%A 党少农
%A 颜
%A 虹
%J 西安交通大学学报(医学版)
%D 2017
%R 10.7652/jdyxb201703003
%X 摘要：目的 探讨围孕期被动吸烟、染烫发、噪音污染、装修污染4种生活因素与新生儿先天性心脏病的关系。方法 采用以医院为基础的病例对照研究方法，对270名病例及1 633名对照进行一对一问卷调查。采用广义线性模型分析围孕期生活因素对先天性心脏病的影响。结果 在建立的2个模型中均未发现妇女围孕期染烫发与先天性心脏病的关联，而围孕期妇女被动吸烟、噪音污染、装修污染均能增加新生儿先天性心脏病发生的风险。校正完所有的混杂因素后发现，被动吸烟、噪音污染、装修污染的OR值分别为1.771(95% CI：1.079～2.909)、2.079(95% CI：1.310～3.298)、2.494(95% CI：1.511～4.116)。结论 妇女围孕期被动吸烟、噪音污染、装修污染是新生儿先天性心脏病发生的危险因素，为预防新生儿先天性心脏病的发生，应注意避免围孕期被动吸烟、噪音污染及装修污染。<br>ABSTRACT: Objective?? To explore the relationship of four kinds of lifestyle factors, namely, prenatal passive smoking, hair dyeing or perming, exposure to noise, living in a house renovated in the past one year, with congenital heart disease. Methods?? A hospital-based case-control study was conducted. Totally 270 mothers in the case group and 1633 mothers in the control group were interviewed through a face-to-face questionnaire survey. A generalized linear model was employed to investigate the association between congenital heart disease and prenatal lifestyle factors. Results?? Both in Model 1 and Model 2, prenatal hair dyeing or perming had no association with congenital heart disease. On the other hand, prenatal passive smoking, exposure to noise and living in a house renovated in the past one year all increased the risk of congenital heart disease. After adjustment for all confounders, the OR values were 1.771 (95% CI: 1.079-2.909), 2.079 (95% CI: 1.310-3.298), and 2.494 (95% CI: 1.511-4.116), respectively. Conclusion?? Prenatal passive smoking, exposure to noise and living in a house renovated in the past one year are the risk factors for congenital heart disease. It is very important to avoid such factors during pre-pregnancy and pregnancy
%K 围孕期生活因素
%K 先天性心脏病
%K 病例对照研究
%K 广义线性模型&lt
%K br&gt
%K prenatal lifestyle factor
%K congenital heart disease
%K case-control study
%K generalized linear model
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201703003