%0 Journal Article
%T Ezrin在三阴性乳腺癌中的表达及意义<br>The expression and significance of Ezrin in human triple negative breast cancer
%A 张
%A 宏
%A 王
%A 文
%A 田
%A 甜
%A 赵茜茜
%A 马兴聪
%A 闫婉君
%A 高晓燕
%A 张淑群
%J 西安交通大学学报(医学版)
%D 2016
%R 10.7652/jdyxb201604021
%X 摘要：目的 研究Ezrin在三阴性乳腺癌中的表达及意义。方法 应用免疫组化SP法测定24例三阴性乳腺癌、58例非三阴性乳腺癌及20例乳腺良性疾病组织中Ezrin的表达，比较各组Ezrin阳性表达率的差异，分析其与三阴性乳腺癌临床病理特征之间的关系。结果 Ezrin在三阴性乳腺癌、非三阴性乳腺癌及乳腺良性疾病组织中的阳性表达率分别为75.00%、48.28%、15.00%，三者比较差异有统计学意义(P<0.01)。三阴性乳腺癌中Ezrin高表达与组织学分级和临床TNM分期有关(P<0.05)，而与患者年龄、肿瘤大小及腋窝淋巴结转移状况无关(P>0.05)。结论 Ezrin在三阴性乳腺癌中高表达，提示其可以作为三阴性乳腺癌预后不良的一个重要指标。<br>ABSTRACT: Objective To study the expression and significance of Ezrin in triple negative breast cancer tissues. Methods We selected 102 cases, including 24 ones of triple negative breast cancer, 58 ones of non-triple negative breast cancer, and 20 of benign breast disease. The expression of Ezrin in all the specimens was detected by SP immunohistochemistry. We observed whether there was any difference between the positive expression rates of Ezrin in the three groups. We also analyzed the correlation between Ezrin expression and clinicopathologic parameters of triple negative breast cancer. Results The positive expression rate of Ezrin in groups of triple negative breast cancer, non-triple negative breast cancer, and benign breast disease was 15.00%, 48.28% and 75.00%, respectively. The difference between the three groups differed significantly (P<0.01). The high expression of Ezrin in triple negative breast cancer had relationship with histological grading and clinical TNM staging (P<0.05), but not with patients’ age, tumor size, or axillary lymph node metastasis (P>0.05). Conclusion Ezrin is highly expressed in triple negative breast cancer tissues; therefore, it can be used as an important indicator of poor prognosis of triple negative breast cancer
%K Ezrin
%K 三阴性乳腺癌
%K 免疫组化&lt
%K br&gt
%K Ezrin
%K triple negative breast cancer
%K immunohistochemistry
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201604021