%0 Journal Article
%T 胃癌的分子机制及靶向诊断研究进展<br>Advances in research on molecular mechanisms and target diagnosis of gastric cancer
%A 和水祥
%A 张
%A 丹
%A 禄韶英
%J 西安交通大学学报(医学版)
%D 2016
%R 10.7652/jdyxb201604001
%X 摘要：胃癌的发生发展涉及多个分子信号通路和许多细胞因子，其中比较重要的包括PI3K/AKT、MAPK通路，HER、VEGF/VEGFR、MET等生长因子及受体家族，COX-2、NF-κB、STAT、白介素家族等炎症相关因子，他们参与了胃癌细胞凋亡抑制、增殖促进、周期调控以及胃癌侵袭迁移、血管生成等过程。这些因子在胃癌中特异性表达，可以作为肿瘤标记物用于胃癌的靶向治疗，相应药物多已进入临床试验阶段。在上述理论基础上，胃癌靶向诊断也有了新的进展，闪烁扫描法、内镜等手段逐渐趋于成熟，但特异性探针的研究多处于临床前期阶段，仍有待进一步的发展。<br>ABSTRACT: Multiple cellular factors and molecular signal pathways including PI3K/AKT pathway; MAPK pathway; growth factors and receptors like HER, VEGF/VEGFR and MET; inflammation-related factors like COX-2, NF-κB, STAT and interleukins, are involved in the occurrence and development of gastric cancer, these factors play a key role in apoptosis inhibition, proliferation promotion and cell cycle regulation of gastric cancer cells, as well as invasion, migration and angiogenesis of stomach malignancy. They are also expressed at a higher level in gastric cancer tissue compared with normal gastric mucosa and characterized as biomarkers, whose target therapies mostly have been in clinical trials. Based on these theoretical foundations, the research on molecular diagnosis of gastric cancer has made some progress.Instruments for target detection tend to be mature. However, the research of molecular probes is still in pre-clinical trials, which remains to be further developed
%K 胃癌
%K 分子机制
%K 靶向治疗
%K 靶向诊断&lt
%K br&gt
%K gastric cancer
%K molecular mechanism
%K target therapy
%K target diagnosis
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201604001