%0 Journal Article
%T 胶囊内镜下非甾体抗炎药相关小肠损伤的特点<br>Features of small bowel injury associated with non-steroidal anti-inflammatory drugs: A video capsule study in obscure gastrointestinal bleeding patients
%A 任牡丹
%A 马文慧
%A 卢桂芳
%A 李雅睿
%A 麻
%A 婧
%A 任
%A 莉
%A 和水祥
%A 卢新兰
%J 西安交通大学学报(医学版)
%D 2018
%R 10.7652/jdyxb201805020
%X 摘要：目的 探讨胶囊内镜(capsule endoscopy, CE)在非甾体抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs)相关小肠黏膜损伤诊断中的临床价值。方法 将57例不明原因消化道出血(obscure gastrointestinal bleeding, OGIB)的患者，根据胶囊内镜检查前2周内是否服用NSAIDs分为服药组及对照组，比较两组患者胶囊内镜下小肠黏膜损伤的发生率、病变分布及病理特点。结果 服药组及对照组胶囊内镜下小肠各类病变发现率分别为90.4%和88.8%(P=0.850)。其中，糜烂发生率服药组明显高于对照组(61.9% vs. 33.3%，P=0.036)；溃疡发现率、出血率服药组与对照组差异均无统计学意义(14.2% vs. 19.4%；14.3% vs. 25.0%，P>0.05)。病变部位分布，服药组近端小肠发现率明显高于对照组(57.1% vs. 25.0%，P=0.015)；小肠黏膜损伤的严重程度，服药组明显高于对照组(61.9% vs. 33.3%，P=0.036)。结论 NSAIDs相关的OGIB患者小肠黏膜损伤的发生率较高，胶囊内镜下主要表现为黏膜糜烂，病灶主要分布于小肠上段，且以重度为主。胶囊内镜检查有利于NSAIDs相关小肠损伤的诊断。<br>ABSTRACT: Objective To investigate the clinical value of capsule endoscopy (CE) in the diagnosis of small intestinal mucosa injury related to non-steroidal anti-inflammatory drugs (NSAIDs). Methods We divided 57 patients with obscure gastrointestinal bleeding (OGIB) into observation group and control group according to whether they had taken NSAIDs 2 weeks before CE. We observed and compared the incidence, distribution and pathological characteristics of small bowel injury between the two groups. Results The rate of various lesions in the small intestine of CE group was (90.4% vs. 88.8%, P=0.85). The rate of intestinal mucosal erosion was higher in observation group than in control group (61.9% vs. 33.3%, P=0.036). There was no significant difference in the incidence of ulcer (14.2% vs. 19.4%) or endoscopic hemorrhage (14.3% vs. 25.0%, P>0.05). The incidence of erosion in proximal small intestine was significantly higher in observation group than in control group (57.1% vs. 25.0%, P=0.015). The severity of small intestinal injury in observation group was significantly higher than that in control group (61.9% vs. 33.3%, P=0.036). Conclusion In OGIB patients, the incidence of small intestinal mucosal injury related to NSAIDs was higher than that in uninfected patients. The major manifestation of NSAIDs-related small intestine injury is mucosal erosion, the mucosal erosion is mainly distributed in the upper part of the small intestine, and the mucosa erosion of patients who are taking NSAIDs is more serious than that of patients who are not taking NSAIDs. CE is beneficial to the diagnosis of NSAIDs-related small intestinal injuries
%K 非甾体抗炎药
%K 小肠损伤
%K 胶囊内镜&lt
%K br&gt
%K non-steroidal anti-inflammatory drug
%K small intestinal injury
%K capsule endoscopy
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201805020