%0 Journal Article
%T 慢性乙型肝炎患者外周血IL-17细胞因子水平及其临床意义<br>Clinical significance of serum IL-17 cytokine in patients with chronic hepatitis B
%A 赵
%A 霞
%A 盛慧萍
%A 杨
%A 岩
%A 程玉娥
%A 晁佩佩
%A 刘玛潇
%J 西安交通大学学报(医学版)
%D 2017
%R 10.7652/jdyxb201701017
%X 摘要：目的 探讨外周血Th17的细胞因子IL-17在不同临床分型慢乙肝患者中的水平及临床意义。方法 选取慢乙肝患者轻度30例、中度34例、重度29例、乙肝肝硬化38例、慢加急性肝衰竭21例，另外选取30例同期健康体检者为对照。检测各组外周血IL-17水平，同时检测肝功能及HBV DNA载量(对照组除外)，并对各检测结果进行统计学分析。结果 ①外周血IL-17水平在健康对照组及慢乙肝轻度、中度、重度和慢加急性肝衰竭组分别为(8.103±2.061)ng/mL、(25.551±7.078)ng/mL、(45.442±18.358)ng/mL、(75.378±19.05)ng/mL、(97.16±17.066)ng/mL，5组间及每两两比较差异有统计学意义(P<0.01)；②健康对照组、乙肝肝硬化代偿组、乙肝肝硬化失代偿组外周血IL-17水平分别为(8.103±2.061)ng/mL、(34.517±8.905)ng/mL、(45.615±15.623)ng/mL，3组间及每两两比较差异均有统计学意义(P<0.01)，且失代偿期组较代偿期组有所增高；③152例试验对象的外周血IL-17水平与ALT、AST、TBIL、HBV-DNA正相关；与血清PTA、ALB负相关；④21例慢加急性肝衰竭患者e抗原阳性组与阴性组中外周血IL-17水平比较差异无统计学意义(P=0.654)；⑤慢加急性肝衰竭患者外周血IL-17水平与MELD评分呈正相关(r=0.533，P=0.013)。结论 慢性乙型肝炎患者外周血IL-17水平随炎症加重而升高，且可能对肝硬化、慢加急性肝衰竭的疾病进展有促进作用。<br>ABSTRACT: Objective To explore the changes of serum cytokine interleukin-17 (IL-17) in patients with chronic hepatitis B of different clinical types and its clinical significance. Methods We selected 30 cases of mild chronic hepatitis B, 34 cases of moderate one, 29 cases of severe one, 38 cases of liver cirrhosis, and 21 cases of acute on chronic liver failure. Another 30 cases over the same period served as the healthy control group. Cytokine IL-17 level in peripheral blood was detected in each group, and all the groups except the control group were detected for liver function and HBV-DNA. These related serum markers were detected and the results were statistically analyzed. Results ① IL-17 in the peripheral blood was (8.103±2.061)ng/mL in healthy control group; (25.551±7.078)ng/mL, (45.442±18.358)ng/mL and (75.378±19.05)ng/mL in the groups with mild, moderate and severe chronic hepatitis B; and (97.16±17.066)ng/mL in acute on chronic liver failure group. Its levels gradually increased with the severity; and there were significantly different among the five groups and between every two groups (P<0.01). The peripheral blood level of IL-17 was (8.103±2.061)ng/mL in the healthy control group, (34.517±8.905)ng/mL in compensatory cirrhosis group, and (45.615±15.623)ng/mL in the decompensated cirrhosis group. These three groups had pairwise comparison, and the difference between every two groups was significant (P<0.01). The peripheral blood level of IL-17 in the decompensated cirrhosis group increased compared with that in the compensatory group. ③ In the 152 cases detected, serum IL-17 level and serum ALT, AST, TBIL, HBV-DNA levels were positively correlated, and serum PTA had negative correlation with the level of IL-17. ④ In the 21 cases of acute on chronic liver failure, the peripheral blood level of IL-17 did not significantly differ between
%K 辅助性T淋巴细胞17
%K 白介素-17
%K 慢性乙型肝炎
%K 乙肝肝硬化
%K 慢加急性肝衰竭&lt
%K br&gt
%K helper T lymphocyte 17
%K interleukin-17
%K chronic hepatitis
%K cirrhosis
%K acute on chronic liver failure
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201701017