%0 Journal Article
%T Protective effects of Dragon's Blood on blood coagulation and NO/iNOS level in myocardium and serum of rats in simulated microgravity<br>Protective effects of Dragon's Blood on blood coagulation and NO/iNOS level in myocardium and serum of rats in simulated microgravity
%A 陈博
%A 邓力
%A 欧婉露
%A 郑志芬
%A 邓玉林
%A 李玉娟
%J 北京理工大学学报（自然科学中文版)
%D 2016
%R 10.15918/j.jbit1004-0579.201625.0122
%X To investigate effects of Dragon's Blood (DB), a traditional Chinese medicine, on blood coagulation and NO/iNOS level in myocardium and serum of rats in simulated microgravity for the first time, Sprague Dawley (SD) rats were randomly divided into six groups:(a) 5-day control group, (b) 5-day model group, (c) 5-day drug group, (d) 21-day control group, (e) 21-day model group, and (f) 21-day drug group. Blood coagulation and NO/iNOS level in myocardium and serum were examined after 5 and 21 days of simulated microgravity respectively. The results showed that blood of tail-suspended rats was in a hypercoagulable state that could not be converted with time extending. Conversely, DB changed these parameters towards normal level and the curative effects became better when tail-suspension lasted till the 21st day. NO concentration of both myocardium and serum for two periods all increased markedly and DB could effectively reduce these increases except that of 21-day myocardium NO. Activity of iNOS increased markedly as early as 5 days and became more serious on the 21st day, while DB showed preventive effect on the 21st day. Western Blot analysis illustrated that the expression of iNOS in the 5-day model group increased significantly over the 5-day control group and the expression in the 5-day drug group dramatically returned to the normal level. The similar trend was observed on the 21-day groups without notable variances. The findings of this study can serve for the further use of Dragon's Blood in space diseases.<br>To investigate effects of Dragon's Blood (DB), a traditional Chinese medicine, on blood coagulation and NO/iNOS level in myocardium and serum of rats in simulated microgravity for the first time, Sprague Dawley (SD) rats were randomly divided into six groups:(a) 5-day control group, (b) 5-day model group, (c) 5-day drug group, (d) 21-day control group, (e) 21-day model group, and (f) 21-day drug group. Blood coagulation and NO/iNOS level in myocardium and serum were examined after 5 and 21 days of simulated microgravity respectively. The results showed that blood of tail-suspended rats was in a hypercoagulable state that could not be converted with time extending. Conversely, DB changed these parameters towards normal level and the curative effects became better when tail-suspension lasted till the 21st day. NO concentration of both myocardium and serum for two periods all increased markedly and DB could effectively reduce these increases except that of 21-day myocardium NO. Activity of iNOS increased markedly as early as 5 days and
%K Dragon's Blood simulated microgravity rats blood coagulation NO/iNOS&lt
%K br&gt
%K Dragon's Blood simulated microgravity rats blood coagulation NO/iNOS
%U http://journal.bit.edu.cn/yw/bjlgyw/ch/reader/view_abstract.aspx?file_no=20160122&flag=1