%0 Journal Article
%T <br>
%A 李鹏
%A 楼张蓉
%A 韩克利
%J 物理化学学报
%D 2017
%R 10.3866/PKU.WHXB201704284
%X 线粒体不仅是细胞的能量单元，还是重要的活性氧产生场所。线粒体内的活性氧与正常的生理功能和人类疾病具有紧密的联系，包括细胞信号传导，损伤核酸蛋白质以及诱导氧化应激。然而，线粒体活性氧和细胞病态之间的复杂联系还研究得不够透彻。有效检测线粒体内活性氧的手段有助于研究线粒体内活性氧在各种人类疾病中所起的作用。近年来，发展了许多具有高灵敏度和选择性的荧光探针用于检测线粒体内活性氧。基于这一点，我们综述了用于选择性检测线粒体内活性氧的小分子荧光探针的研究进展，并详细讨论了荧光探针的设计、合成、特点及其应用。<br>In addition to being the energy powerhouse of the cell, mitochondria are an important source of reactive oxygen species (ROS) during the process of molecular oxygen metabolism. Mitochondrial ROS are closely associated with normal physiological functions as well as human diseases, and participate in cell signaling, nucleic acid and protein damage, and oxidative stress induction. However, the complicated interplay between mitochondrial ROS and the cellular pathological state has not been fully elucidated. It is expected that research on the mitochondrial ROS undertaking in the molecular pathogenesis of human diseases would benefit from development of efficient tools for the detection of these ROS. In recent years, an increasing number of fluorescent probes for mitochondrial ROS with high sensitivity and selectivity have been developed. Here, we present a review of the recent advances in small molecular fluorescent probes for selective detection of ROS inside the mitochondria. In this review, the design, synthesis, characteristics, and applications of the published fluorescent probes for mitochondrial ROS are discussed in detail
%U http://www.whxb.pku.edu.cn/CN/Y2017/V33/I8/1573