%0 Journal Article
%T 有氧运动对老年自发性高血压大鼠心肌纤维化的影响<br>Effect of Aerobic Exercise on Myocardial Fibrosis in Aged Spontaneously Hypertensive rats
%A 尹懿
%A 张琳
%A 徐安杰
%A 石丽君
%J 北京体育大学学报
%D 2015
%R 10.19582/j.cnki.11-3785/g8.2015.12.010
%X 摘要：目的：探讨有氧运动对老年自发性高血压大鼠（SHR）心肌纤维化的影响及其可能的基质金属蛋白酶表达机制。方法：12只16月龄雄性SHR大鼠随机分为安静组（SHR-SED）和运动组（SHR-EX），另选用12只同龄雄性WKY大鼠随机分为安静组（WKY-SED）和运动组（WKY-EX）。SHR-EX组和WKY-EX组进行8周有氧运动，坡度0°，20 m/min，60 min/day，5 d/周。8周后，测量各组大鼠血压、全心质量指数、心肌组织中胶原蛋白的表达以及基质金属蛋白酶-9和基质金属蛋白酶组织抑制剂-1的表达情况。结果：1）SHR-SED组大鼠收缩压显著高于WKY-SED组，SHR-EX组和WKY-EX组的收缩压分别显著低于SHR-SED组和WKY-SED组；2）SHR-SED组全心质量指数显著高于WKY-SED组，SHR-EX组显著低于SHR-SED组；3）SHR-SED组相比于WKY-SED组心肌胶原容积分数、I、III型胶原表达显著升高，SHR-EX组相比于SHR-SED组显著降低；4）SHR-SED组相比于WKY-SED组MMP-9以及MMP-1/TIMP-1显著升高，SHE-EX组相比于SHR-SED组显著降低。结论：老年自发性高血压大鼠心肌呈现明显纤维化，其中MMP-9与TIMP-1的表达平衡是其重要原因；有氧运动则可通过抑制MMP-9与TIMP-1的表达失衡从而有效改善老年高血压心肌纤维化程度。<br>Abstract: Objective: This study detected the effect of aerobic exercise on myocardial fibrosis in aged spontaneously hypertensive rats（SHR）and explored the possible mechanism of the expression of matrix metalloproteinase. Methods: Twelve male SHRs were randomly assigned to a sedentary group (SHR-SED) and an exercise training group (SHR-EX)，and also 12 male WKYs were randomly assigned to a sedentary group (WKY-SED) and an exercise training group (WKY-EX). SHR-EX and WKY-EX underwent treadmill training at 20 m/min for 60 min, 5 d/wk, for 8 weeks. After 8 weeks, blood pressure, heart mass index, the expression of myocardial collagen fiber, and the protein expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were examined. Results: 1) The systolic blood pressure(SBP) in SHR-SED group was significantly higher than that in WKY-SED group. Also, the SBP in SHR-EX group and WKY-EX group was significantly lower than that in SHR-SED group and WKY-SED group respectively; 2) The heart mass index was significantly higher in SHR-SED group than that in WKY-SED group, and in SHR-EX group, it was significantly lower than that of SHR-SED group; 3) The CVF, expression of I, III collagen fibrils in SHR-SED group was significantly higher compared with WKY-SED group, and it was significantly lower in SHR-EX group compared with SHR-SED group; 4) Compared with WKY-SED group, MMP-9 and MMP-1/TIMP-1 were significantly higher in SHR-SED group, and compared with SHE-SED group, it was significantly lower in SHR-EX group. Conclusion: Aging induces significant myocardial fibrosis in SHR, which may be related to the imbalance of MMP-9 and TIMP-1; aerobic exercise can inhibit this imbalance and markedly suppress the aging-induced myocardial fibrosis in SHR
%K aerobic?exercise hypertension myocardial fibrosis collagen fibril matrix metalloproteinases
%U http://xuebao.bsu.edu.cn/ch/reader/view_abstract.aspx?file_no=20151210&flag=1