%0 Journal Article
%T 低强度运动通过抑制海马CA1区theta节律改善大鼠焦虑情绪<br>Low Intensity Exercise Improve Anxiety Emotion Through Inhibiting Theta Thythm of Hippocampus CA1 in Rats
%A 孙丽娜
%A 李海春
%A 张欣欣
%A 祁金顺
%J 北京体育大学学报
%D 2015
%R 10.19582/j.cnki.11-3785/g8.2015.07.013
%X 摘要：目的：观察低强度运动对大鼠焦虑情绪和海马CA1区局部场电位theta节律活动的影响。方法：将雄性Wistar大鼠随机分为对照组（control group, CG）和运动组（exercise group, EG），其中CG不进行运动，EG大鼠进行为期4周的低强度跑台运动。此后进行旷场实验，检测大鼠焦虑情绪的变化。行为学实验结束后，采用在体多通道局部场电位电生理记录技术，分析大鼠海马CA1区theta节律的改变。结果：在旷场实验中，与CG相比，EG大鼠在中央区域停留时间和活动距离均显著增加（P<0.05）；同时，EG大鼠海马CA1区由夹尾刺激诱导的局部场电位theta节律的功率峰值较CG大鼠明显降低（P<0.05），而theta节律功率峰值对应的频率不存在明显的组间差异（P<0.05）。结论：低强度运动可使大鼠焦虑情绪降低，探索行为活跃并导致海马theta节律功率压抑。这提示，低强度运动所引起的情绪变化可能与海马theta节律的功率峰值降低有关，海马局部场电位theta节律的改变可能是运动改善焦虑情绪的神经调控机制之一。<br>Abstract: Objective: This study aimed at observing the effects of low intensity exercise on anxiety emotion and theta rhythm of hippocampus CA1. Methods: Male Wistar rats were randomly divided into control group (CG) and exercise group (EG). EG rats underwent 4 weeks low intensity treadmill exercise while CG rats didn’t. Rats’ anxiety emotion was detected by the open field tests, and hippocampus CA1 theta rhythm was recorded and analyzed by multi-channel local field potentials in vivo. Results: In the open field tests, compared with CG, the residence time in the central area and the total movement distance of EG were increased significantly (P < 0.05); compared with CG, the peak power of hippocampus CA theta rhythm induced by tail pinch in EG significantly decreased (P < 0.05), but the peak power frequency of the theta rhythm had no significant difference (P > 0.05). Conclusions: Low intensity exercise may ease anxiety emotion, promote exploratory behaviors and inhibit hippocampus theta rhythm power. It is indicated that the effect of low intensity exercise on emotion may be related to the decrease of hippocampus theta rhythm peak power, and the change of the local field potential theta rhythm in hippocampus might be one neural regulation mechanism
%K low intensity exercise anxiety local field potential hippocampus theta rhythm
%U http://xuebao.bsu.edu.cn/ch/reader/view_abstract.aspx?file_no=20150713&flag=1