%0 Journal Article %T 慢性吗啡处理及戒断对社会新颖性和食物寻求行为的影响<br>Effects of Chronic Morphine Exposure and Withdrawal on Social Novelty- and Food-seeking Behaviors %A 古再丽努尔·买买提 %A 王建礼 %A 詹泊 %A 刘朝宝 %A 陈墨轩 %J 四川动物 %D 2016 %X 中文摘要：阿片肽在调控社会性和非社会性天然奖赏中具有重要作用。寻求天然奖赏的动机与动物的情绪状态有关。吗啡注射和戒断会引起动物不同的情绪状态。本研究探讨了吗啡处理期和戒断期是否会影响动物对2种类型天然奖赏(社会新颖性和食物)的寻求行为。雄性小鼠连续注射14 d的吗啡(10 mg·kg -1,生理盐水作对照组),在最后一次注射20 min后,依次检测了小鼠的运动性及对熟悉个体、陌生个体和食物的接近时间。戒断7 d后,以上行为变量(除运动性)被再次检测。结果表明,盐水处理及戒断的小鼠对陌生个体的接近时间明显多于熟悉个体,且表现出对食物的偏好。吗啡处理的小鼠运动性增加,接近陌生个体和熟悉个体的时间差异无统计学意义,但仍表现出对食物的偏好。与盐水组相比,吗啡戒断降低了小鼠对食物的偏好,但不影响对陌生个体的接近时间。这些结果表明,吗啡会损害寻求社会新颖性和食物的动机;慢性吗啡处理和戒断对这2种天然奖赏的寻求行为有不同的影响,这种差异可能与吗啡经验诱导的不同神经适应有关。<br>英文摘要：Opioid peptides play a crucial role in the control of social and non-social natural rewards. The motivation to seeking natural rewards is associated with the emotional state of an animal. The exposure and withdrawal from morphine provokes different emotional states. The present study assessed whether morphine exposure and withdrawal affects the seeking behaviors of two types of natural rewards: social novelty and food. Male mice were administered morphine (10 mg·kg -1 twice daily, or saline in control) for 14 days. 20 minutes after the last injection, locomotor activity and the approach to familiar and unfamiliar conspecifics or food were examined. Subsequently, the social novelty-seeking and food-seeking behaviors of mice that had undergone a seven-day morphine or saline withdrawal were examined. During the phases of saline exposure and withdrawal, we observed that mice would prefer food and spend more time on approaching the unfamiliar conspecifics rather than on the familiar conspecifics. Morphine exposure increased the locomotion and the morphine-exposed mice spent a similar amount of time on approaching the unfamiliar and familiar conspecifics. Morphine exposure did not significantly affect the food-seeking behavior. Compare to saline controls, morphine withdrawal lowered the time spent on approaching to food, while there were no specific effects in social novelty-seeking. These findings indicated that morphine experience significantly impaired the appetitive motivations to social stimuli and food; the incentives for the two stimuli were affected differently by chronic exposure and withdrawal from morphine, and these behavioral changes may be associated with morphine experience-induced different neuroadaptations. 2016,(1): 44-51 收稿日期：2015-07-21 DOI：10.11984/j.issn.1000-7083.20150237 分类号：Q959.837 基金项目：国家自然科学基金项目(31260513, 31460565); 北方民族大学研究生创新基金项目(YCX1526); 国家大学生创新实验项目(201411407039) 作者简介：古再丽努尔·买买提(1990-), 女, 硕士研究生 *通讯作者：王建礼, 男, 博士, 副教授, 主要从事行为生理学研究, E-mail:wang_jianli@163.com 参考文献： Aragona BJ, Detwiler JM, Wang ZX. 2007. Amphetamine reward in the monogamous prairie vole[J]. Neuroscience Letter, 418(2): %K 吗啡 %K 戒断 %K 天然奖赏 %K 社会刺激 %K 食物< %K br> %K 英文关键字：morphine %K abstinence %K natural reward %K social stimuli %K food %U http://www.scdwzz.com/viewmulu.aspx?qi_id=1524&mid=47694&xuhao=7