%0 Journal Article
%T 益生菌联合肠内营养制剂对炎症性肠病的疗效观察
%A 王若晨
%A 韩婷
%A 李伟
%J 同济大学学报(医学版)
%D 2018
%R 10.16118/j.1008-0392.2018.04.021
%X 目的 探讨采用益生菌联合肠内营养（enteral nutrition, EN）制剂与单独应用EN制剂两种不同营养方式对于炎症性肠病（inflammatory bowel disease, IBD）的疗效比较。 方法 2016年1月—2017年3月接受治疗的IBD患者，随机将其分为观察组(n=60)和对照组(n=60)。观察组使用益生菌联合EN制剂；对照组单独使用EN制剂。观察两组溃疡性结肠炎（ulcerative colitis, UC）和克罗恩病（Crohn’s disease, CD）患者在进行干预前后的营养指标和炎性指标等，并进行统计学分析。结果 共有120例纳入本研究。对照组和观察组各60例，干预前后，UC观察组红细胞计数（red blood cell count, RBC）、血清总蛋白（total protein, TP）、血红蛋白（hemoglobin, Hb）、白蛋白(albumin, Alb)、前白蛋白(prealbumin, PA)、K+等均明显高于对照组（P＜0.05）；C-反应蛋白（C-reaction protein, CRP），红细胞沉降率（erythrocyte sedimentation rate, ESR），IgG明显低于对照组（P＜0.05）；IgA明显高于对照组（P＜0.05）。CD观察组PA、K+等明显高于对照组（P＜0.05），ESR、IgG等明显低于对照组（P＜0.05）。结论 益生菌联合EN制剂用于治疗IBD比单独使用EN制剂对于营养指标和炎症指标的改善更加有效，且其对UC的疗效较CD更为明显。</br>Objective To investigate the efficacy of probiotics combined with enteral nutrition (EN) in treatment of inflammatory bowel disease (IBD). Methods One hundred and twenty patients with ulcerative colitis (UC) or Crohn’s disease (CD) treated from January 2016 to March 2017 were divided into study group (n=60) and control group(n=60). Patients in study group received probiotics combined with EN preparation, while the control group received EN preparations alone. The nutritional indexes and inflammatory indexes of patients were measured and compared before and after the treatment in two groups. Results After treatment for UC patients, the levels of red blood cell count（RBC）, total protein （TP）, hemoglobin（Hb）, albumin （Alb）, prealbumin（PA）, IgA and kalium（K+）in study group were significantly higher than those in control group (P<0.05) ; while the levels of C-reaction protein（CRP）, erythrocyte sedimentation rate (ESR) and IgG were significantly lower than those of control group (P<0.05). For CD patients the levels of PA and K in the study group were significantly higher than those in the control group (P<0.05), and the ESR and IgG were significantly lower than those in the control group (P<0.05) after treatment. Conclusion Probiotics combined with EN formulation is more effective than using EN formulation alone in treatment of IBD and the nutrition index and inflammation index of patients are improved, and the effect on UC is more marked than CD
%K 肠内营养 益生菌 炎症性肠病 疗效&lt
%K /br&gt
%K probiotics enteral nutrition inflammatory bowel disease efficacy
%U http://tjyxxb.cnjournals.cn/ch/reader/view_abstract.aspx?file_no=20180421&flag=1