%0 Journal Article
%T 神经节苷脂治疗老年帕金森病疗效观察
%A 李健
%A 谢南姿
%A 王娟
%A 王海峰
%J 同济大学学报(医学版)
%D 2015
%R 10.16118/j.1008-0392.2015.02.015
%X 目的 探讨神经节苷脂治疗老年帕金森病患者临床症状的疗效。方法60例帕金森病患者随机分为两组,两组病情(震颤、强直、行走、语言)Webster评分差异无统计学意义(P>0.05)。治疗组每日给予神经节苷脂100ml静脉滴注,对照组予丹参20ml静脉滴注。两组均给予左旋多巴每日300mg,分3~4次服用,共2周。每个患者开始时都作血常规、尿常规、肝功能、肾功能、血糖、血脂检查,用以评价药物的安全。比较两组治疗前后临床症状Webster评分变化。结果 治疗组、对照组各30例,治疗后疗效有显著性差异；两组患者治疗前后临床症状Webster评分变化提示治疗组在改善强直、震颤、姿势、面容、步态、语言、自我照顾等各方面的差异均有显著性；而对照组仅在改善强直、步态方面差异有显著性。结论 神经节苷脂对改善老年帕金森患者临床症状有显著疗效。</br>Objective To compare efficacy of gangliosides with Salvia miltiorrhiza injection for elderly patients with Parkinson's disease(PD). MethodsSixty elderly patients with Parkinson's disease were randomly assigned in two groups, there were no significant differences in Webster scores of disease severity between two groups (P>0.05). Thirty patients received intravenous infusion of 100ml ganglioside daily and another 30 patients received 20ml Salvia miltiorrhiza injection intravenously; patients in both groups were also given oral levodopa 300mg/d for 2 weeks. Laboratory tests including blood routine, urine routine, liver function, renal function and blood glucose were performed. Webster score were evaluated before and after treatment in two groups. ResultsAccording to Webster scores the symptoms of PD in ganglioside group including rigidity, tremor, posture, face, language, self-care were significantly improved; while in Salvia miltiorrhiza group only rigidity and gait were improved after treatment. ConclusionGangliosides has significant effect in improving the clinical symptoms of elderly patients with Parkinson's disease
%K 神经节苷脂 帕金森病 老年人&lt
%K /br&gt
%K Ganglioside Parkinson's disease elderly
%U http://tjyxxb.cnjournals.cn/ch/reader/view_abstract.aspx?file_no=20150215&flag=1