%0 Journal Article
%T 应加强慢性鼻—鼻窦炎内在型研究<br>Promoting the study of chronic rhinosinusitis endotypes
%A 曹平平
%A 廖 波
%A 刘 争
%J 医学争鸣
%D 2018
%X 基于现行诊疗指南，有相当一部分慢性鼻— 鼻窦炎（CRS）患者经过充分药物治疗和手术干预仍不能有效控制病情。越来越多的证据表明CRS是一种高度异质性疾病。加强开展CRS内在型研究，明确不同内在型病理生理过程，并依此为基础开展流行病学、遗传学、药物及手术治疗研究，构建CRS精准或个性化诊疗策略，有利于提高疗效，规避不必要的医疗干预。<br>Despite following the current chronic rhinosinusitis (CRS) treatment guidelines, a significant number of CRSpatients remain poorly controlled after adequate medical and surgical treatments. Increasing evidences suggest that CRSis a heterogeneous disease. Promoting CRS endotype study and identifying underlying pathophysiologic mechanisms arecritical for the understanding of CRS. These studies will prosper the epidemiologic and genetic studies and the developmentof precise and individualized therapeutic strategies for CRS
%K 慢性鼻— 鼻窦炎
%K 异质性疾病
%K 内在型<br>chronic rhinosinusitis
%K heterogenous disease
%K endotype
%U http://yxzm.paperonce.org/oa/DArticle.aspx?type=view&id=201806006