%0 Journal Article
%T 记录每一个神经细胞的每一次冲动意义何在？<br>Does “recording every spike from every neuron” make sense?
%A 杨雄里
%J 医学争鸣
%D 2015
%X 神经细胞（神经元）在受到刺激时产生电脉冲（锋电位，动作电位）。这些“全或无”锋电位的波形 极相似，但它们的放电模式因多种因素而变，这些因素包括刺激参数、其他神经元的活动等。甚至一个特定的神 经元，其活动特征在发育过程中会进一步发生精细的修饰，以适应周围的环境。鉴于这些原因，笔者认为，在引 用“记录每一个神经元的每一个锋电位”这样的表述来渲染“大脑活动图谱”计划必须十分谨慎，尽力避免这样 的表述在公众中可能产生的误导。我们需要达成共识：“记录每一个神经元的每一个锋电位”，即使在一个局部 神经元环路中（更勿论整个大脑），既不可行，也无意义。<br>Nerve cells (neurons) generate electrical impulses (spikes/action potentials) upon stimulation. While these “all or none” spikes look extremely similar in waveforms, their firing patterns may be rather changeable, depending on a variety of factors, including stimulus parameters, activities of other neurons, and so on. Moreover, even for a specific neuron the features of its activity could be largely and precisely modified during development to adapt to the environment. Given the above facts, the author argues that it should be cautious in citing the phrase “record every spike from every neuron” to highlight the “Brain Activity Mapping” Project and any possible misunderstanding this expression might induce in the public should be avoided. We need to come to an understanding that it is not only infeasible, but also meaningless to“record every spike from every neuron” even in a local circuit, let alone in the brain
%K 大脑活动图谱
%K 神经元
%K 锋电位<br>brain activity mapping
%K neuron
%K spike
%U http://yxzm.paperonce.org/oa/DArticle.aspx?type=view&id=201503002