%0 Journal Article
%T 血管内皮损伤可能是血管钙化和骨质疏松的共同始动因素<br>Vascular endothelial dysfunction may be a common initialfactor of development of vascular calcification and osteoporosis
%A 赵莉
%A 刘文利
%A 刘艳
%A 赵玉霞
%J 医学争鸣
%D 2017
%X 血管钙化和骨质疏松的发病存在密切关系，血管钙化促进骨质疏松的发生、发展，而骨质疏松患者亦同时存在血管钙化。本文阐述了血管钙化的形成过程及其形成机制，认为血管壁过量沉积的钙来源于骨骼，而且钙离子在血管和骨骼间的转运是可逆的。血管内皮损伤促进钙离子从骨骼中释放出来，转运至血管壁，从而促进血管壁肌肉收缩、凝血及炎症过程，进而促进血管壁的修复；反复的血管壁受损，导致钙离子不断从骨骼转运至血管壁，从而导致血管壁钙化和骨质疏松。<br>Numerous epidemiological studies have demonstrated an intimate relationship between vascularcalcification and osteoporosis. Vascular calcification accelerates the progress of osteoporosis, and osteoporosis patients alsoare discovered simultaneously suffering vascular calcification. Vascular calcification is an actively regulated process andshares many features with bone development and metabolism. The excessively deposited calcium in vascular walls is frombones. The calcium traffic is bidirectional between vessel walls and bones. Calcium, which is transferred to vessel wallsfrom bones induced by vascular endothelial dysfunction, promotes muscle contraction, blood coagulation, inflammatoryprocess, and the restoration of blood vessel walls. Repeated endothelial dysfunction leads to the excessive calciumtransporting from bones to vessel walls, inducing ultimately vascular calcification and osteoporosis
%K 内皮损伤
%K 血管钙化
%K 骨质疏松<br>vascular endothelial dysfunction
%K vascular calcification
%K osteoporosis
%U http://yxzm.paperonce.org/oa/DArticle.aspx?type=view&id=201701006