%0 Journal Article
%T 口腔微生物移位定植——中医药干预结肠炎癌转化新窗口<br>Oral microorganism transplantation/colonization —New consideration of traditional Chinese medicine intervention in IBD-CRC
%A 谢子妍
%A 由凤鸣
%A 金 钊
%A 郑 川
%A 严 然
%A 夏孟蛟
%J 医学争鸣
%D 2018
%X 结肠炎癌转化并非一个孤立事件，微生物移位定植诱发细胞基因表达、黏附及增殖等行为是其演进基础并贯穿全程。研究表明，慢性牙周炎患者罹患结肠癌风险较高，与口腔特定菌移位定植于肠道引发的级联反应密切相关。中医药调控口腔微生态效果显著、干预结肠炎癌转化临床证据丰富，但鲜少将二者结合阐发。本文以此为切入点，通过探讨中医药视角下口腔— 结肠病变纠缠的微生态学内涵、口腔特定菌移位定植于肠道动态过程与中医病机的表征关联等，认为中医药调控口腔微生态干预结肠炎癌转化切实可行，且口腔微生态可反映结肠炎癌动态演进、评估疗效，为结肠<br>Inflammatory bowel disease-associated colorectal cancer (IBD-CRC) is not an isolated disease. It is tied up tothe biomechanical behaviors such as cell gene expression, adhesion and proliferation induced by microbial transplantation/colonization, and the biomechanical behaviors go through the whole IBD-CRC process. Recent studies have revealedthat patients with chronic periodontitis have a higher risk of CRC. Frontier studies have also found that Fusobacteriumnucleatum translocated and colonized in colonic epithelial cells promotes downstream cascade and drives the progressionof CRC. The controlling effect of traditional Chinese medicine (TCM) on oral microorganism is remarkable and abundantclinical evidence shows that TCM can intervene in IBD-CRC. But almost no one considers oral microecology as a keypoint to study TCM intervention in IBD-CRC. In this article, we discussed the relationship between oral microecology andcolorectal diseases from the perspective of TCM as well as the correlation between the dynamic process of specific oralbacteria colonized in the intestine and the pathogenesis. We found that TCM regulation of oral microecology is feasible inthe intervention of IBD-CRC, and oral microecology has the role of reflecting the variable process of IBD-CRC and thetreatment efficacy. Therefore, oral microecology research can provide a new observation window for the early detection,treatment and outcome evaluation of CRC
%K 口腔微生态
%K 移位定植
%K 具核梭杆菌
%K 结肠炎癌转化
%K 中医药<br>oral microecology
%K transplantation/colonization
%K Fusobacterium nucleatum
%K inflammatory bowel diseaseassociated colorectal cancer
%K traditional Chinese medicine
%U http://yxzm.paperonce.org/oa/DArticle.aspx?type=view&id=201806014