%0 Journal Article
%T 中国优生及辅助生殖的挑战与出路
%A 孙方臻
%A 孙鹿希
%A 黄秀英
%A 张慧琴
%A 印惠荣
%A 颜宏利
%A 刘燕敏
%A 孙颖浩
%J 第二军医大学学报
%D 2017
%R 10.16781/j.0258-879x.2017.07.0832
%X 人类辅助生殖技术给我国日益增长的不孕不育患者带来了希望，但同时也增加了后代出生缺陷甚至成人疾病的发生风险。本文阐述了影响优生的配子、胚胎、母源因素以及辅助生殖安全性，旨在强调提升下一代健康水平应以配子/胚胎健康为本，可借助基因组学新技术降低遗传性出生缺陷发生率，防控胚胎发育源性成年病风险。</br>Human assisted reproductive technology has brought hope to the growing infertility population, but also has increased the risk of birth defects and even adult disease incidence. Here we discussed the gametes, embryos and maternal factors which affect eugenics and assisted reproductive safety. With the help of the new genomics technology such as the next generation sequencing, we can greatly reduce the incidence of hereditary birth defects, and prevent and control embryonic developmental risk of adult diseases
%K 辅助生殖技术 先天畸形 基因组学 表观遗传&lt
%K /br&gt
%K assisted reproductive techniques congenital abnormalities genomics epigenetics
%U http://www.ajsmmu.cn/ajsmmu/ch/reader/view_abstract.aspx?file_no=20170531&flag=1