%0 Journal Article
%T 嵌段共聚物胶束形态的影响因素
%A 徐敏
%A 陈鸿铭
%A 邹豪
%A 高静
%J 第二军医大学学报
%D 2017
%R 10.16781/j.0258-879x.2017.03.0360
%X 嵌段共聚物胶束作为一种有效的药物递送系统受到广泛关注，其具备增加疏水性药物溶解度、延长药物体内循环时间、提高药物稳定性、增强药物治疗效果等优点。胶束的形态可引起其载药和体内分布、药动学行为等性质的重大变化。本文通过对国内外文献的研读，重点探讨了影响嵌段聚合物胶束形态的重要因素（聚合物、制备因素、药物及其他），为今后该类型给药系统的设计提供参考。</br>Block copolymer micelle has attracted great attention as an effective drug delivery system. It has many merits, such as increasing the solubility of hydrophobic drug, prolonging the in vivo drug circulation time, improving drug stability and enhancing the therapeutic effect of anticancer agents. Micelle morphology plays an important role in its drug loading, in vivo distribution and pharmacokinetic behavior. Here in this paper we provided a review of the critical factors affecting the morphology of block copolymer micelles (polymer, preparation factors, drug and others) for future reference
%K 嵌段共聚物 胶束 形态 药物载体&lt
%K /br&gt
%K block copolymers micelle morphology drug carriers
%U http://www.ajsmmu.cn/ajsmmu/ch/reader/view_abstract.aspx?file_no=20160595&flag=1