%0 Journal Article
%T 射波刀治疗周围型非小细胞肺癌临床分析
%A 方芳
%A 居小萍
%A 张火俊
%A 卢明智
%A 陈樱
%A 于春山
%A 曹洋森
%A 王晓艳
%A 刘永明
%A 张晓青
%J 第二军医大学学报
%D 2016
%R 10.16781/j.0258-879x.2016.01.0098
%X 目的 研究射波刀治疗周围型非小细胞肺癌的近期疗效和不良反应,评估射波刀治疗周围型肺癌的安全性和有效性。 方法 对66例周围型非小细胞肺癌患者进行射波刀治疗,金标追踪25例,肺追踪35例,椎体追踪6例;65%~75%等剂量线覆盖计划靶区 (planning target volume,PTV),总剂量为42~60 Gy,分割次数4~6次,生物等效剂量 (biological equivalent dose,BED) 为71.4~150.0 Gy。治疗后4~12周CT扫描评价近期疗效;随访时间为11~29个月,中位时间为18个月。 结果 全组患者完全缓解31例,部分缓解28例,稳定5例,疾病进展2例,有效率89.4%,肿瘤大小和BED是影响疗效的重要因素 (P=0.019, P=0.007)。 结论 射波刀治疗周围型非小细胞肺癌安全、有效,可获得较好的肿瘤控制率,远期疗效需进一步随访。</br>Objective To study the short-time outcome and adverse effect of cyberknife in treatment of peripheral non-small cell lung cancer, so as to evaluate the safety and efficacy of cyberknife in treatment of peripheral lung cancer. Methods A total of 66 patients with peripheral non-small cell lung cancer completed their cyberknife radiosurgery, with real-time target tracking through fiducial marker implantation in 25 cases, X-sight lung synchrony in 35 cases, and X-sight spine tracking in 6 cases. Total prescribed dosage ranged from 42 to 60 Gy, with 4 to 6 fractions prescribed to the 65%-75% isodose lines for planning target volume. The biological effective dose (BED) was 71.4-150.0 Gy. The follow-up time was 11-29 months and the median time was 18 months. Results A total of 31 patients had complete radiographic responses, 28 had partial response, 5 patients had stable disease and 2 had progressive disease. The response rate was 89.4%. Tumor size and BED were the significant factors affecting the result of treatment (P=0.019, P=0.007). Conclusion Cyberknife radiosurgery treatment is effective and safe for peripheral non-small cell lung cancer. It can achieve satisfactory tumor control rate, while the long term outcome needs further follow-up
%K 射波刀 肺肿瘤 周围型肺癌 非小细胞肺癌 立体定向放射治疗&lt
%K /br&gt
%K cyberknife lung neoplasms peripheral lung cancer non-small-cell lung carcinoma stereotactic radiotherapy
%U http://www.ajsmmu.cn/ajsmmu/ch/reader/view_abstract.aspx?file_no=20150136&flag=1