%0 Journal Article
%T 巯基化壳聚糖-吡诺克辛钠-层状双氢氧化物纳米复合物滴眼液的研究
%A 张洁
%A 池慧波
%A 程艳菊
%A 操锋
%J 中国药科大学学报
%D 2015
%X 将壳聚糖-谷胱甘肽(CG)与吡诺克辛钠(PRN)共插层于层状双氢氧化物(LDH)中，制备有机-机杂化层状双氢氧化物纳米复合物(CG-PRN-LDH)滴眼液，并对其在家兔角膜前的滞留行为进行考察。采用共沉淀法制备了Mg-Al-PRN-LDH、Zn-Al-PRN-LDH和共插层的CG-PRN-LDH纳米复合物。通过X-RD、FTIR、TEM、激光粒度仪对纳米复合物进行表征。比较了3种纳米复合物和PRN在人工泪液中的释放行为，考察了PRN-LDH、CG-PRN-LDH纳米复合物滴眼液和市售滴眼液在家兔角膜前的滞留行为。PRN-LDH、CG-PRN-LDH纳米复合物滴眼液的AUC0-t分别为市售滴眼液的3.72和7.59倍，平均滞留时间(MRT)分别为市售滴眼液的2.18和2.60倍，结果表明有机-机杂化纳米复合物CG-PRN-LDH能显著延长PRN在角膜前的滞留时间。</br>Ophthalmic solution of organic-inorganic layered double hydroxides hybrid nanocomposites based on layered double hydroxides(LDH)intercalated with pirenoxine sodium(PRN)and chitosan-glutathione(CG)was prepared, characterized and evaluated using rabbit precorneal retention. Mg-Al-PRN-LDH, Zn-Al-PRN-LDH and CG-PRN-LDH were synthesized by co-precipitation. The nanocomposites were characterized by laser particle sizer, powder X-ray diffraction(X-RD), fourier transform infrared spectra(FTIR)and transmission electron micrographs(TEM). The release of PRN from Mg-Al-PRN-LDH, Zn-Al-PRN-LDH, and CG-PRN-LDH nanocomposites and API in artificial tear was compared. Based on in vivo precorneal retention studies, PRN-LDH and CG-PRN-LDH nanocomposite dispersions showed significantly higher AUC(3. 72-, 7. 59-folds)and MRT(2. 18-, 2. 60-folds)than that of the commercial eye drops group. Organic-inorganic layered double hydroxides hybrid nanocomposites CG-PRN-LDH dispersions could remarkably improve precorneal retention of PRN
%K 层状双氢氧化物 吡诺克辛钠 滴眼液 巯基化壳聚糖 纳米复合物 共沉淀法 体外释放 角膜前滞留&lt
%K /br&gt
%K layered double hydroxides pirenoxine sodium eye drops thiolated chitosan hybrid nanocomposites co-precipitation method in vitro release precorneal retention
%U http://www.zgykdxxb.cn/jcpu/ch/reader/view_abstract.aspx?file_no=20150211&flag=1