%0 Journal Article
%T RP-HPLC测定替诺福韦及其有关物质
%A 刘超
%A 钟惺
%A 席艳琼
%A 汤银霞
%A 蒋礼
%A 王福军
%A 蒲通
%A 曾苏
%J 中国药科大学学报
%D 2015
%X 为了研究替诺福韦的有关物质，合成了3个有关化合物，建立了替诺福韦RP-HPLC分离条件(以Agilent ZORBAX SB-C18为色谱柱，以甲醇-0.02 mol/L磷酸二氢钾为流动相梯度洗脱，检测波长为260 nm)。结果显示替诺福韦有3种潜在的有关物质。所建立的分析方法准确度高，重复性好，适用于替诺福韦有关物质的含量检测。</br>To investigate the related substances of tenofovir, 3 related substances were synthesized. RP-HPLC analytical method was developed using Agilent ZORBAX SB-C18 column. The mobile phase composed of methanol and 0. 02 mol/L potassium dihydrogen phosphate. Linear gradient elution was used and the detection wavelength was 260 nm. 3 impurities were found in tenofovir. The established method was accurate and reproducible, and it can be applied for the related substances test in tenofovir
%K 替诺福韦 RP-HPLC 有关物质 杂质&lt
%K /br&gt
%K tenofovir RP-HPLC related substances impurities
%U http://www.zgykdxxb.cn/jcpu/ch/reader/view_abstract.aspx?file_no=20150110&flag=1