%0 Journal Article
%T 益智仁中二苯基庚烷类化合物的血管生成抑制活性
%A 高晓平
%A 陈丽晓
%A 殷志琦
%A 蒋玲玲
%A 林清华
%A 何明芳
%J 中国药科大学学报
%D 2015
%X 探讨益智仁中两个已知二苯基庚烷类化合物Yakuchinone A和Yakuchinone B以及结构类似物姜黄素(curcumin)的血管生成抑制活性。采用了转基因荧光斑马鱼为体内实验动物模型，人脐静脉内皮细胞(HUVEC)为体外实验模型，评价了上述3个化合物的活性及毒性。以血管生成抑制指数(AI)代表化合物的活性与毒性之比。结果表明，论是体外实验还是体内实验，姜黄素的血管生成抑制作用最强而毒性最低，Yakuchinone A次之，Yakuchinone B抑制活性最低而毒性最强。因此，姜黄素为三者中最佳的血管生成抑制剂。</br>This study investigated the anti-angiogenic activities of two diarylheptanoids, together with a structure analogue, curcumin. The activity and toxicity of these three compounds were compared using transgenic zebrafish as in vivo model and human umbilical vein endothelial cell(HUVEC)as in vitro model. Anti-angiogenic index(AI)was used as the ratio between LC50 and EC50. The results suggested that in both in vitro and in vivo assay, curcumin exerted the most potent anti-angiogenic effect but with lowest toxicity among these compounds; Yakuchinone A was the second potent; Yakuchinone B has the lowest activity but with the highest toxicity in all three compounds. Taken together, curcumin was the best angiogenic inhibitor in these three diarylheptanoids
%K 血管生成 斑马鱼 人脐静脉内皮细胞 姜黄素 二苯基庚烷化合物 Yakuchinone A Yakuchinone B&lt
%K /br&gt
%K angiogenesis zebrafish HUVEC curcumin diarylheptanoid Yakuchinone A Yakuchinone B
%U http://www.zgykdxxb.cn/jcpu/ch/reader/view_abstract.aspx?file_no=20150112&flag=1