%0 Journal Article
%T 荷载紫杉醇介孔二氧化硅纳米粒的制备及体外性能
%A 张雪
%A 苏志桂
%A 薛玲静
%A 张灿
%J 中国药科大学学报
%D 2015
%X 介孔二氧化硅纳米粒(mesoporous silica nanoparticle，MSN)作为药物载体已成为纳米给药系统研究的热点。以序孔道的MSN为载体，以溶剂吸附法负载化疗药物紫杉醇(PTX)，从而制备得到PTX@MSN。考察了PTX@MSN的理化性质、药物体外释放行为和体外抗肿瘤活性等特性。研究结果表明，PTX@MSN载药量为(23.76±1.14)%，在水性介质中分散良好，粒径约为250 nm，电位为-(8.01±1.81)mV。PTX@MSN具有药物缓释特性，24 h后PTX累积释放率为(23.62±2.15)%。细胞毒性结果显示，空白MSN生物安全性良好，而PTX@MSN组对人肝癌HepG2细胞的杀伤作用较市售Taxol组强。本研究为MSN递送抗肿瘤药物提供一定的理论与应用基础。</br>Mesoporous silica nanoparticle as drug carrier has become the new research focus in the field of nano-drug delivery system in recent years. In this study, paclitaxel-loaded msesoporous silica nanoparticle(PTX@MSN)was manufactured by the solvent adsorption. In vitro studies revealed that PTX@MSN was well dispersed in aqueous medium with particle size of 250 nm, the potential of -(8. 01±1. 81)mV and drug loading efficiency of(23. 76±1. 14)%. PTX@MSN showed the sustained-release characteristics with the cumulative PTX of release(23. 62±2. 15)% at 24 h. In additions, the cytotoxicity investigation indicated that blank MSNs were biocompatible while PTX@MSN group showed improved in vitro anti-tumor activity against HepG2 cell when compared with Taxol group. In conclusion, MSN is a promising platform to build drug delivery systems for tumor therapy
%K 介孔二氧化硅纳米粒 紫杉醇 体外释放 抗肿瘤活性&lt
%K /br&gt
%K mesoporous silica nanoparticles paclitaxel in vitro drug release anti-tumor activity
%U http://www.zgykdxxb.cn/jcpu/ch/reader/view_abstract.aspx?file_no=20150603&flag=1