%0 Journal Article
%T Current Research of the Roles of IL-35 in Tumor Progression
%A Chongbiao HUANG
%A Ye TIAN
%A Yan CUI
%A Jie XU
%A Liang XIN
%A Xueling YANG
%A Daliang QI
%J Öйú·Î°©ÔÓÖ¾
%D 2016
%R : 10.3779/j.issn.1009-3419.2016.04.09
%X Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an ¦Á chain P35 and a ¦Â chain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.
%K Interleukin
%K Interleukin-35
%K Tumor
%K Tumor immunology
%U http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2016.04.09