%0 Journal Article
%T Expression and Clinical Significance of MAGE-C2 in Lung Adenocarcinoma
%A Kang GUO
%A Mengshi LU
%A Ping XU
%A Hongmei LI
%J Öйú·Î°©ÔÓÖ¾
%D 2016
%R : 10.3779/j.issn.1009-3419.2016.02.09
%X Background and objective The aim of this study is to detect the expression of melanoma antigen-C2 (MAGE-C2) in lung adenocarcinoma tissues and adjacent non-cancerousous tissues and analyze its clinical significance. Methods The expression level of MAGE-C2 mRNA and MAGE-C2 protein were measured in 87 cases of lung adenocarcinoma tissues and adjacent non-cancerous tissues were detected by Real-time fluorescence quantitative PCR and Western blot. Results Over-expression of the MAGE-C2 mRNA and MAGE-C2 protein were observed in lung adenocarcinoma tissues (53/87, 60.9%), but nor in adjacent non-cancerous tissues. The expressions of MAGE-C2 mRNA and MAGE-C2 protein were closely associated with clinical stage, metastasis and differentiation (P<0.05). The expression rate of MAGE-C2 mRNA had no relationship with gender, age, smoking (P>0.05). The expression of MAGE-C2 had an adverse effect on overall survival rate (P<0.05). Conclusion Over-expression of the MAGE-C2 mRNA and protein is existed in lung adenocarcinoma. The high expression of MAGE-C2 may be closely related to the occurrence and development in lung adenocarcinoma. MAGE-C2 may predict a poor prognosis and could be as a novel lung adenocarcinoma molecule marker.
%K Lung neoplasms
%K Tumor marker
%K MAGE-C2
%U http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2016.02.09