%0 Journal Article
%T Advances in Research of Antitumor Mechanisms of Isothiocyanates
%A Huimin WANG
%A Ke XU
%J Öйú·Î°©ÔÓÖ¾
%D 2017
%R : 10.3779/j.issn.1009-3419.2017.03.11
%X Isothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and producing reactive oxygen species in vitro and in vivo. Recent studies showed that ITCs also inhibit metastasis of cancer cells, induce endoplasmic reticulum stress and autophagy. This review summarizes the antitumor mechanisms of ITCs.
%K Isothiocyanate
%K Anti-tumor activity
%K Apoptosis
%K Cell cycle arrest
%K Metastasis
%K Autophagy
%U http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2017.03.11