%0 Journal Article
%T T-peptide Enhances the Killing Effects of Cisplatinum on Lung Cancer
%A Hongyi ZHANG
%A Minghui LIU
%A Ying LI
%A Yongwen LI
%A Song XU
%A Zhenhua PAN
%A Mingbiao LI
%A Haiyang FAN
%A Hongyu LIU
%A Jun CHEN
%J Öйú·Î°©ÔÓÖ¾
%D 2017
%R : 10.3779/j.issn.1009-3419.2017.02.01
%X Background and objective T peptide is extensively used in anti-tumor treatment. The aims of this study were to investigate whether T peptide enhances cisplatinum efficiency while reducing its side effects and to identify its effective mechanisms. Methods (1) Human macrophage U937 cells were treated with T peptide and/or cisplatinum. The levels of tumor necrosis factor-¦Á (TNF-¦Á) and interferon-¦Ã (IFN-¦Ã) of each group were detected by enzyme-linked immunosorbent assay (ELISA); (2) Xenograft mouse models of human lung cancer were treated with T peptide and/or cisplatinum once every five days for three times. Tumor volumes were measured during treatment; (3) The percentages of macrophages in the peripheral blood of the xenograft mouse models were measured by FACS. Results (1) Compared with other groups, the level of TNF-¦Á was significantly higher in the human macrophage U937 cells that were treated with T peptide combined with cisplatinum. The levels of IFN-¦Ã were significantly higher in human macrophage U937 cells that were treated with T peptide alone or T peptide combined with cisplatinum; (2) In the xenograft mouse models, T peptide combined with cisplatinum treatment significantly inhibited tumor growth without weight loss compared with the other groups; (3) The percentages of macrophages in the peripheral blood were significantly higher in the xenograft mouse models that were treated with T peptide combined with cisplatinum compared with in the other groups. Conclusion T peptide promotes macrophage proliferation and increases tumor cell killing factors (TNF-¦Á, IFN-¦Ã) in vitro. Moreover, T peptide enhances the efficacy of cisplatin and reduces its toxicity in vivo.
%K Lung neoplasms
%K T peptide
%K TNF-¦Á
%K IFN-¦Ã
%U http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2017.02.01