%0 Journal Article
%T Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy¡ª¡ª£¿AKT/m-TOR Pathway and Resistance to Cancer Therapy
%A Liudmila V SPIRINA
%A Irina V KONDAKOVA
%A Natalia V TARASENKO
%A Elena M SLONIMSKAYA
%A Evgeny A USYNIN
%A Alexey K GORBUNOV
%A Zahar A YURMAZOV
%A Svetlana Yu CHIGEVSKAYA
%J Öйú·Î°©ÔÓÖ¾
%D 2018
%R : 10.3779/j.issn.1009-3419.2018.01.09
%X Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy.
%U http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2018.01.09