%0 Journal Article
%T 自噬与肿瘤关系研究新进展
%A 曹建平
%A 夏大静
%J 浙江大学学报(医学版)
%D 2015
%R 10.3785/j.issn.1008-9292.2015.03.014
%X 自噬是一种高度保守的细胞代谢过程,细胞中的蛋白质和细胞器被包裹在自噬体中并运送到溶酶体降解。已发现自噬与神经退行性疾病、肿瘤等多种疾病关系密切,尤其是与肿瘤的关系研究备受关注。自噬在肿瘤的发生、发展中有“双刃剑”作用,即自噬抑制肿瘤的发生但在肿瘤形成后会促进肿瘤发展。肿瘤化疗或放疗过程中会诱导自噬的发生,且一般认为是保护作用。自噬是肿瘤治疗的潜在重要靶标,但由于自噬在肿瘤中的很多作用并未明确,欲通过调控自噬来提高肿瘤疗效尚待更多研究。</br>Abstract: Autophagy is an evolutionarily well conserved cellular catabolic process.Cellular proteins and organelles are engulfed to autophagosomes and eventually delivered to lysosomes for degradation. Autophagy is closely associated with a variety of human diseases especially cancer. At present, it has been widely accepted that autophagy is a “double-edged sword” in cancer:it blocks tumorigenesis at the early stage, while it facilitates tumor development at the promotion and progression stage. Moreover, autophagy can be induced by chemotherapy and radiotherapy, which is generally play a pro-survival function. Thus, autophagy is an important target for cancer therapy, and suppression of autophagy to enhance the efficacy of cancer therapeutic agents is a novel strategy in cancer therapy under active clinical trials. Key words: Neoplasms Autophagy Review
%K Neoplasms Autophagy Review
%U http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2015.03.014