%0 Journal Article
%T 茶多酚对肿瘤免疫逃逸的抑制机制研究进展
%A 孔德栋
%A 赵悦伶
%A 王岳飞
%A 徐平
%J 浙江大学学报(农业与生命科学版)
%D 2018
%R 10.3785/j.issn.1008-9209.2018.05.021
%X 茶多酚是茶叶中主要的活性物质。研究表明，茶多酚可以通过对细胞周期、基因表达、信号转导、转录因子等的调控来抑制肿瘤细胞的生长和诱导其凋亡，从而发挥抗肿瘤作用。然而，茶多酚的结构特点使得其在生物体内的利用度较低，造成茶多酚直接作用于肿瘤细胞的抗肿瘤机制很难在生物体内实现，以至于茶多酚抗肿瘤机制至今尚未明确。肿瘤免疫学认为，肿瘤免疫逃逸在肿瘤的发生和发展过程中起着重要作用，而以髓系抑制性细胞为代表的负向调节抗肿瘤免疫应答的免疫抑制性细胞则是肿瘤免疫逃逸的重要原因。研究发现，茶多酚可以通过抑制肿瘤微环境中的免疫抑制细胞来阻滞肿瘤免疫逃逸，这为茶多酚抗肿瘤机制研究提供了新的思路。本文从茶多酚抗肿瘤研究现状、肿瘤免疫逃逸机制、茶多酚对免疫逃逸作用及其在肿瘤免疫治疗中的应用等方面，对近年来的相关研究进行了总结和综述，以期为茶多酚抗肿瘤机制研究提供参考。 通讯作者: 徐平（https://orcid.org/0000-0003-1599-7408）；王岳飞（https://orcid.org/0000-0002-0278-4625） E-mail: zdxp@zju.edu.cn；zdcy@zju.edu.cn</br>Abstract: Tea polyphenols (TP) are the main active compounds in tea leaves. It is found that TP could inhibit cancer cell growth and induce cell apoptosis via modulating cell cycle, gene expression, signal transduction and transcription factor, etc. However, due to the low bioavailability of TP, it is hard for TP to work on cancer cells directly, which leading to the anti-tumor mechanism effect of TP is still unclear. As known, tumor immune escape is found to play a key role in tumor genesis and growth; immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), are able to regulate anti-tumor immune response negatively, and mainly contribute to tumor immune escape. Recently, TP have been found to relieve immune escape and suppress spontaneous neuroblastoma cells through MDSCs, which provide a new sight into understanding the anti-tumor effect of TP. In this paper, the recent researches on the effects of tea polyphenols on immunosuppressive cells were reviewed in order to provide a reference for studying the anti-tumor mechanisms of tea polyphenols. Key words: tea polyphenols immune escape myeloid-derived suppressor cells anti-tumor
%U http://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2018.05.021