%0 Journal Article
%T 放大内镜结合窄带成像技术评估早期食管癌浸润深度价值的Meta分析*
%A 李婷园
%A 张烁
%J 中国内镜杂志
%D 2016
%R 10.3969/j.issn.1007-1989.2016.09.001
%X 摘要： 目的 系统评价放大内镜结合窄带成像技术（ME-NBI）对评估早期食管癌浸润深度的临床价值。方法 计算机检索Embase、Pubmed、Web of Science、Cochrane Library、CBM、CNKI、万方及维普数据库，检索年限从建库至2016年2月，全面收集有关ME-NBI评估食管癌浸润深度相关的研究。根据纳入标准筛选文献，并按诊断试验评价标准（QUADAS）系统评价文献质量并提取数据，采用Stata 12.0版软件进行Meta分析。结果 最终纳入6篇文献，提取出7组数据，包括319例患者的366例病变进行合并分析。ME-NBI评估早期食管癌的敏感度（Se）为93.8%[95%可信区间（95%CI）：0.886～0.967）]，特异度（Sp）为75.2%（95%CI：0.658～0.827），阳性似然比（LR+）3.779（95%CI：2.685～5.318），阴性似然比（LR-）0.083（95%CI：0.044～0.155），综合受试者工作特征曲线（SROC）下面积（AUC）0.80（95%CI：0.770～0.840），诊断比值比（DOR）45.658（95%CI：21.006～99.240）。结论 ME-NBI对评估早期食管癌浸润深度的诊断准确性较高，可作为临床术前诊断黏膜内癌的有效工具，对指导临床选择合理的手术方式和治疗手段具有重要意义。</br>Abstract: Objective?To evaluate the accuracy of magnifying endoscopy with narrow-band imaging (ME-NBI) for detecting early esophageal cancer invasion depth. Methods We searched Embase, Pubmed, Web of Science, Cochrane Library, CBM, CNKI, Wanfang and VIP databases from inception to Feb.2016. Domestic articles related to the accuracy of ME-NBI detecting the early esophageal cancer invasion depth were collected comprehensively. The quality of the papers was evaluated by quality assessment of diagnostic accuracy studies (QUADAS). Data analysis was conducted by Stata 12.0 software. Results Seven group data from six studies including 319 patients with 366 lesions met the inclusion criteria. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, SROC area under the curve and DOR were 93.8 % (95 % CI: 0.886~0.967), 75.2 % (95 % CI: 0.658~0.827), 3.779 (95 % CI: 2.685～5.318), 0.083 (95 % CI: 0.044~0.155), 0.80 (95 % CI: 0.770~0.840) and 45.658 (95 % CI: 21.006~99.240). Conclusions The results suggest that ME-NBI may be an effective tool for detecting invasion depth of early esophageal cancer, which plays an important role in clinical selection of surgical approach and treatment.
%K magnifying endoscopy narrow band imaging early esophageal cancer invasion depth
%U http://www.zgnjzz.com/CN/abstract/abstract8974.shtml