%0 Journal Article
%T 流体剪应力在骨髓基质干细胞成骨向分化中作用机制的研究进展
%A 杨屹羚
%A 张鹏
%A 江凌勇
%J 医用生物力学
%D 2018
%X 细胞在体内受到流体剪应力、机械应变、流体静压力等机械应力的作用，其中流体剪应力（fluid shear stress, FSS）被认为是维持骨稳态及骨改建过程中最重要的应力。目前研究多集中在FSS对骨细胞及成骨细胞的作用上，骨髓基质干细胞（bone mesenchymal stem cells, BMSCs）的研究相对较少。BMSCs对骨改建及治疗具有重要的意义，BMSCs对FSS的应答越来越受到关注。BMSCs对FSS的反应涉及细胞骨架、基质刚度及弹性、成骨信号等方面。总结FSS在BMSCs内的力转导机制、对其分化及功能的改变等方面的研究进展，为今后构建组织工程化骨、骨病变的治疗等研究提供思路。</br>Cells are exposed to mechanical stress, such as fluid shear stress (FSS), mechanical strain, hydrostatic pressure in vivo. FSS is considered to be the most important stress during bone homeostasis and remodeling. At present, most studies are mainly about the FSS effect on osteocytes and osteoblasts. However, the effects of FSS on bone mesenchymal stem cell (BMSCs) are not fully understood. BMSCs are of great significance in bone reconstruction and clinical treatment, so researchers increasingly focus on the response of BMSCs to FSS. The response of BMSCs to FSS depends on the alteration of cytoskeleton, matrix stiffness and elasticity, osteogenic signaling pathways and so on. In this review paper, the recent researches about the mechanotransduction mechanism of FSS, and its effect on differentiation and function of BMSCs are summarized, so as to provide new insights for studying construction of tissue engineered bone and treatment of bone diseases.
%K 流体剪应力
%K 骨髓基质干细胞
%K 力转导
%K 机械敏感性&lt
%K /br&gt
%K fluid
%K shear
%K stress
%K (FSS)
%K bone
%K mesenchymal
%K stem
%K cells
%K (BMSCs)
%K mechanotransduction
%K mechanosensitivity
%U http://www.mechanobiology.cn/yyswlx/ch/reader/view_abstract.aspx?file_no=201804015&flag=1