%0 Journal Article
%T 信号转导和转录活化因子3在骨髓基质干细胞成骨向分化中的作用
%A 周巳入
%A 张鹏
%A 江凌勇
%J 医用生物力学
%D 2017
%X 正畸牙移动是压力侧骨吸收和张力侧骨形成动态平衡的骨改建过程。在机械力诱导下成骨细胞、破骨细胞等发生相应的功能的变化。具有多向分化潜能的骨髓基质干细胞（bone mesenchymal stem cells, BMSCs)为力学敏感细胞，在体外适当机械刺激下，其生物学特性发生功能性变化，适应性应答力学刺激的最佳要求，表现为成骨分化，此过程需多种信号分子。作为一种转录因子，信号转导和转录活化因子3（signal transducer and activator of transcription 3，STAT3）可参与细胞增殖、分化、存活、凋亡、转化、细胞免疫等重要的生理病理过程。现已有研究证明，STAT3可以调控BMSCs骨向分化过程。综述STAT3对BMSCs骨向分化的影响及可能作用机制的最新研究进展。</br>Orthodontic tooth movement is a dynamic process, which includes bone resorption on the pressure side and osteogenesis on the tension side. Bone mesenchymal stem cells (BMSCs), which are force-sensitive cells, have potentials for differentiation into cells with various types. Their biological characteristics can change functionally according to the appropriate stimulation in vitro, in order to reach the optimal demand of the stimulation. Many signal pathways are involved in osteogenesis. Signal transducers and activators of transcription 3 (STAT3) is a ubiquitously expressed transcription factor, mediating cell proliferation, differentiation, survival, apoptosis and cellular immunity. It has been reported that STAT3 can regulate the differentiation process of BMSCs into osteoblasts. This paper summarizes the recent progress about effect of STAT3 on bone differentiation of BMSCs and the possible mechanism.
%K 骨髓基质干细胞
%K 信号转导和转录活化因子3
%K 成骨分化&lt
%K /br&gt
%K Bone
%K mesenchymal
%K stem
%K cells
%K (BMSCs)
%K Signal
%K transducer
%K and
%K activator
%K of
%K transcription
%K 3(STAT4)
%K Osteogenesis
%U http://www.mechanobiology.cn/yyswlx/ch/reader/view_abstract.aspx?file_no=201701017&flag=1