%0 Journal Article
%T 动载荷作用下骨重建力学调控机制
%A 马宗民
%A 李淑娴
%J 医用生物力学
%D 2015
%R 10.3871/j.1004-7220.2015.04.346
%X 目的 探讨动载荷作用下骨重建的力学调控机制。方法 对骨重建力学调控机制进行分析，吸纳力学疲劳强度理论思想，提出动载荷作用下骨重建力学调控机制；选取损伤作为力学激励，建立动载荷骨重建模型；分析动态载荷成骨效果优于静态载荷现象，数值模拟运动防治骨质疏松。结果 动态载荷成骨效果优于静态载荷现象得到较为合理的解释；运动量增加10%~30%，骨密度增加3.13%~8.61%。结论 动载荷作用下骨重建的力学调控机制可为机械振动防治骨代谢相关疾病提供理论指导，是骨重建力学调控理论的补充和完善。</br>Objective To discuss the mechanostat of bone remodeling under dynamic loads. Methods By analysis on mechanostat of bone remodeling and absorption from the idea of mechanical fatigue strength theory, the mechanostat of bone remodeling under dynamic loads was developed. Damage was selected as the mechanical stimulus under dynamic loads and the model of bone remodeling under dynamic loads was proposed. Physical exercise for prevention and treatment of osteoporosis was simulated to analyze the biomechanical phenomenon why the osteogenesis effect under dynamic loads seems better than that under static loads. Results The biomechanical phenomenon as mentioned above was reasonably explained. An increase of 10%-30% in physical exercise could cause an increase of 3.13% 8.61% in bone mineral density. Conclusions The mechanostat of bone remodeling under dynamic loads will provide theoretical guidance for using mechanical vibration to treat or prevent diseases related to bone metabolism, which is the supplement and improvement for mechanostat of bone remodeling.
%K 骨重建
%K 力学调控机制
%K 动态载荷
%K 疲劳&lt
%K /br&gt
%K Bone
%K remodelling
%K Mechanostat
%K Dynamic
%K load
%K Fatigue
%U http://www.mechanobiology.cn/yyswlx/ch/reader/view_abstract.aspx?file_no=201504009&flag=1