%0 Journal Article
%T 神经肽 Y 基因多态性和精神分裂症的关联研究<br>Relationship between neuropeptide Y gene polymorphism and schizophrenia
%A 赵静
%A 吕钦谕
%A 陆颖
%A 胡国芹
%A 鲍晨曦
%A 朱明环
%A 贾思
%A 程小燕
%A 耿瑞杰
%A 姜雅琴
%A 禹顺英
%A &lt
%A br&gt
%A ZHAO Jing
%A Lü Qin-yu
%A LU Ying
%A HU Guo-qin
%A BAO Chen-xi
%A ZHU Ming-huan
%A JIA Si
%A CHENG Xiao-yan
%A GENG Rui-jie
%A JIANG Ya-qin
%A YU Shun-ying
%A YI Zheng-hui
%J 上海交通大学学报（医学版）
%D 2017
%R 10.3969/j.issn.1674-8115.2017.12.001
%X [  ] 目的 · 探讨中国汉族人群神经肽 Y(NPY) 基因多态性与精神分裂症的相关性。方法 · 采用 TaqMan 探针基因分型技术对 678 例精神分裂症患者 ( 病例组 ) 及 685 例正常对照者 ( 对照组 ) 的 NPY 基因多态性（rs16148、rs1859290、rs16147、rs16478）进行分型。应用 SHEsis 在线软件比较各组间的等位基因频率、基因型频率、单倍型频率分布有无差异。结果 · rs16478 位点基因型频率分布在成年起病精神分裂症（AOS）组和对照组间存在边缘统计学差异（χ2=6.66，P=0.036，P 校正 =0.144）。在隐性模式下，rs1859290 位点 CC基因型的频率分布在男性病例组和对照组间差异有统计学意义（P=0.012，OR=0.97，95%CI 为 0.94 ～ 0.99，P 校正 =0.048）。单倍型CCTA（由 rs16148、rs1859290、rs16147、rs16478 构成）的频率分布在男性 AOS 组和对照组间的差异有统计学意义（8.1% vs 13.2%，OR=0.57，P=0.010，P 校正 =0.040）。结论 · 在中国汉族人群中，NPY 基因可能是精神分裂症的易感基因。<br>：[Abstract] Objective · To explore the association between neuropeptide Y (NPY) gene polymorphism and schizophrenia in Chinese Han population. Methods · Four single nucleotide polymorphism (SNP) loci (rs16148, rs1859290, rs16147, and rs16478 in NPY gene) were selected and genotyped by TaqMan genotyping assay in a case-control study with 678 schizophrenia cases (case group) and 685 healthy controls (control group). The allele, genotype and haplotype frequencies distribution of the SNPs between the groups were compared with SHEsis online software. Results · The distribution of genotype frequency of locus rs16478 showed a nominal statistically difference between the adult-onset schizophrenia (AOS group) and control group (χ2=6.66, P=0.036, P correction=0.144). Under recessive inherited model, the distribution of CC genotype frequency of locus rs1859290 showed statistically difference between the male schizophrenia cases and control group (P=0.012, OR=0.97, 95%CI 0.94-0.99, P correction=0.048). The distribution of haplotype CCTA (consisted of rs16148, rs1859290, rs16147, and rs16478) frequency showed statistically difference between the male AOS group and control group (8.1% vs 13.2%, OR=0.57, P=0.010, P correction=0.040). Conclusion · The polymorphisms in NPY gene may be associated with schizophrenia in Chinese Han population
%K 神经肽 Y
%K 精神分裂症
%K 关联分析
%K 单核苷酸多态性
%K &lt
%K br&gt
%K neuropeptide Y
%K schizophrenia
%K association study
%K single nucleotide polymorphism
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11737.shtml