%0 Journal Article
%T 卵巢癌相关成纤维细胞的研究进展<br>An update about role of ovarian cancer-associated fibroblasts
%A 卜时夏
%A 赖东梅&lt
%A br&gt
%A BU Shi-xia
%A LAI Dong-mei
%J 上海交通大学学报（医学版）
%D 2016
%R 10.3969/j.issn.1674-8115.2016.08.026
%X 上皮性卵巢癌是女性生殖系统肿瘤中病死率最高的恶性肿瘤。肿瘤微环境内卵巢癌细胞与卵巢癌相关成纤维细胞间的交互影响在肿瘤的发展中起到了重要的作用。该文综述了卵巢癌相关成纤维细胞的最新研究进展，包括起源、在卵巢癌恶性进展中的作用、在卵巢癌诊断及预后评估中的价值，并探讨卵巢癌相关成纤维细胞作为潜在治疗靶点的可能。<br>： Epithelial ovarian cancer (EOC) remains the leading cause of gynecological cancer-related death. In the tumor microenvironment, the reciprocal inter-communication between ovarian cancer cells and ovarian cancer-associated fibroblasts (OCAFs) plays an important role in the progression of ovarian cancer. This review discusses the latest research progresses about OCAFs, including their possible origins, their effects on the progression of ovarian cancer, the potential diagnostic and predictive value of OCAFs, and the potential of OCAF-targeted therapy
%K 卵巢癌
%K 肿瘤微环境
%K 肿瘤相关成纤维细胞
%K &lt
%K br&gt
%K ovarian cancer
%K tumor microenvironment
%K cancer-associated fibroblasts
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11270.shtml