%0 Journal Article %T TRIM28在肿瘤发生及胚胎发育中的作用<br>Roles of TRIM28 in tumorigenesis and embryogenesis %A 刘晔 %A 王尹瑜 %A 许晶晶 %A 黄荷凤< %A br> %A LIU Ye %A WANG Yin-yu %A XU Jing-jing %A HUANG He-feng %J 上海交通大学学报(医学版) %D 2018 %R 10.3969/j.issn.1674-8115.2018.07.023 %X TRIM28是一个包含多个结构域的大分子蛋白,属于人类三聚体蛋白家族中的一员。该家族共计包含60余种蛋白,以存在4个保守结构域即RING指、B-box 1型和2型以及亮氨酸卷曲螺旋结构为主要特征。TRIM28主要与含KRAB结构域(Kruppelassociated box domain)的转录因子相互作用,从而发挥转录共激活或共抑制作用,并在肿瘤发生、细胞分化、胚胎发育的调控中发挥重要作用。<br>:TRIM28, known as a kind of macro-molecules, consists of multiple domains and belongs to one of human tripartite motif-containing proteins families. This superfamily contains more than 60 proteins in total and is characterizedfour conservative domains, also referred to the RBCC domain, which is a RING (really interesting new gene) finger, two B-boxes (type 1 and type 2) and a leucine zipper coiled-coil region. TRIM28 plays its pivotal roles in transcriptional co-activation or co-repressioninteracting directly with transcription factors, within which is a Kruppel-associated box domain (KRAB domain). Moreover, itis critical during the development of embryos, thedifferentiation of cells and the regulation of cancers %K 转录调节 %K 共激活子 %K 共抑制子 %K 肿瘤 %K 表观遗传 %K 甲基化 %K < %K br> %K transcriptional regulation %K co-activator %K co-repressor %K cancer %K epigenetics %K methylation %U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11984.shtml