%0 Journal Article
%T Toll样受体2在炎症相关性胃癌中作用的研究进展<br>Research progresses of the role of Toll-like receptor-2 in inflammation-associated gastric carcinoma
%A 周燚
%A 李继坤&lt
%A br&gt
%A ZHOU Yi
%A LI Ji-Kun
%J 上海交通大学学报（医学版）
%D 2016
%R 10.3969/j.issn.1674-8115.2016.07.025
%X 炎症是宿主防御系统的一部分，它可以对抗入侵的病原体，保护宿主。然而，炎症同样可以通过Toll样受体（TLR）诱导内源性介质，促进肿瘤发生发展。了解TLR2与胃癌之间的关系及可能的作用机制可为炎症相关性胃癌的治疗提供新方法。该文就TLR2的结构、功能、TLR2与炎症相关性胃癌的关系及其可能的致癌机制作一简要综述。<br>： Inflammation is a part of the host defense system and can protect the host against invading pathogens. However, inflammation can also induce endogenous mediators via Toll-like receptors (TLR)，which can promote the occurrence and development of tumor. Understanding the relationship between TLR2 and gastric carcinoma and the possible mechanisms may provide new methods for the treatment of inflammation-associated gastric carcinoma. This paper reviews the structure and function of TLR2, the relationship between TLR2 and inflammation-associated gastric carcinoma, and possible carcinogenic mechanism
%K Toll样受体
%K 胃癌
%K 炎症
%K &lt
%K br&gt
%K Toll-like receptor
%K gastric carcinoma
%K inflammation
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11233.shtml