%0 Journal Article
%T APPL1与心血管疾病的研究进展<br>Research progresses of APPL1 and its role in cardiovascular diseases
%A 陈翠
%A 申锷 &lt
%A br&gt
%A CHEN Cui
%A SHEN E
%J 上海交通大学学报（医学版）
%D 2016
%R 10.3969/j.issn.1674-8115.2016.11.028
%X APPL1是与脂联素受体直接结合的连接蛋白，它包含3个主要功能区域近羧基端的PTB结构域、近氨基端的BAR结构域和位于两者之间的PH结构域。APPL1在不同组织、器官中均有表达，介导胰岛素及脂联素转导通路。APPL1直接与膜受体和信号蛋白等相互作用，参与细胞的存活、凋亡、染色质重塑等过程。APPL1通过相关通路参与抗心肌细胞凋亡，对抗心房肥大及纤维化，以及心力衰竭过程；APPL1还可通过参与调节内皮细胞NO的产生及协调其与血管收缩效应因子的平衡发挥血管保护作用；APPL1信号转导通路在脂联素调节心脏代谢活动中也发挥重要作用。<br>： APPL1 is a connexin that directly connects with adiponectin receptor, containing three main functional domains, i.e. phosphotyrosine binding domain (PTB) close to carboxyl terminus, Bin1/amphiphysin/rvs167 (BAR) close to amino terminus, and pleckstrin homology domain (PH) between PTB and BAR. APPL1 expresses in different tissues and organs, regulating insulin-signaling pathway and adiponectin-signaling pathway. APPL1 plays critical roles in processes such as cell apoptosis, cell survival, and chromatin remodeling by directly interacting with membrane receptors and signaling proteins, as well as fighting against myocardial apoptosis, atrial hypertrophy and fibrosis, and heart failure via relevant pathways. APPL1 can protect vessels through involving in regulating the production of endothelial cell NO and coordinating the balance between NO and vasoconstrictor effectors. APPL1 signal transduction pathway also plays an important role in mediation of the heart metabolism via adiponectin
%K APPL1
%K 心血管疾病
%K 脂联素
%K &lt
%K br&gt
%K APPL1
%K cardiovascular diseases
%K adiponectin
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11367.shtml