%0 Journal Article
%T Ras信号通路与抑郁症神经可塑性机制<br>Ras signaling pathway and neural plasticity mechanism of depression
%A 王凡
%A 张晨
%A 方贻儒&lt
%A br&gt
%A WANG Fan
%A ZHANG Chen
%A FANG Yi-ru
%J 上海交通大学学报（医学版）
%D 2015
%R 10.3969/j.issn.1674-8115.2015.10.025
%X 抑郁症的确切病因及病理机制尚不清楚。近几年，越来越多的证据提示神经可塑性机制在抑郁症发病及治疗中的作用，其中神经营养因子在神经可塑性中发挥着极其重要的作用。Ras相关信号通路作为一条重要的神经营养因子受体下游信号通路在神经可塑性中发挥着重要的作用。该文对Ras信号通路与抑郁症神经可塑性机制的相关研究进行综述。<br>： The pathogenesis of depression has not been clearly elucidated yet. In recent years, more and more evidences highlight the role of neural plasticity mechanism in the pathogenesis and treatment of depression. Particularly, neurotrophic factors are critical for the neural plasticity. Meanwhile the Ras signaling pathway, a vital downstream signaling pathway of the neurotrophic factor receptor, plays an important role in the neural plasticity. This paper reviews studies relevant to Ras signaling pathways and the neural plasticity mechanism of depression
%K 抑郁症
%K Ras信号通路
%K 神经可塑性
%K 神经营养因子
%K &lt
%K br&gt
%K depression
%K Ras signaling pathways
%K neural plasticity
%K neurotrophic factors
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract10910.shtml