%0 Journal Article
%T 黄体生成素受体mRNA结合蛋白的研究进展<br>Research progresses of luteinizing hormone receptor mRNA binding protein
%A 范梦夏
%A 乔洁&lt
%A br&gt
%A FAN Meng-xia
%A QIAO Jie
%J 上海交通大学学报（医学版）
%D 2015
%R 11.3969/j.issn.1674-8115.2015.06.025
%X 黄体生成素受体（LHR）在生殖和发育过程中发挥重要作用。女性排卵前期的黄体生成素（LH）峰及药理剂量的人绒毛膜促性腺激素（hCG）可导致LHR的下调，而在受体下调的大鼠卵巢细胞质中发现LHR mRNA结合蛋白（LRBP）。研究表明，LH/hCG与受体结合后激活cAMP/PKA/ERK通路及miR-122表达，导致LRBP表达量增加；LHR mRNA与LRBP结合后，诱导翻译沉默，并转移至P小体，导致LHR mRNA降解，与排卵前期受体的脱敏过程密切相关。该文就LRBP的研究进展进行综述。<br>： Luteinizing hormone receptor (LHR) plays a crucial role in the processes of reproduction and development. LHR can be down-regulated in response to preovulatory luteinizing hormone (LH) surge or by the administration of a pharmacological dose of human chorionic gonadotropin (hCG). LHR mRNA binding protein (LRBP) has been identified in ovarian cytoplasm of rats with down-regulated receptor. Researches show that the binding of LH/hCG and their receptors can stimulate the cAMP/PKA/ERK signaling pathway and expression of miR-122, which result in the increase of LRBP expression. The binding of LRBP with LHR mRNA can induce the suppression of translation and transfer to the p-bodies, which is closely relevant to the desensitivity of LHR during preovulatory phase. This paper reviews the research progresses of LRBP
%K 黄体生成素受体
%K 黄体生成素受体mRNA结合蛋白
%K P小体
%K &lt
%K br&gt
%K luteinizing hormone receptor
%K luteinizing hormone receptor mRNA binding protein
%K P-bodies
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract10770.shtml