%0 Journal Article
%T 非编码RNA在多囊卵巢综合征中的作用研究进展<br>Research advances in the roles of ncRNAs in polycystic ovary syndrome
%A 杨倩
%A 周承亮
%A 潘洁雪
%A 黄荷凤&lt
%A br&gt
%A YANG Qian
%A ZHOU Cheng-liang
%A PAN Jie-xue
%A HUANG He-feng
%J 上海交通大学学报（医学版）
%D 2016
%R 10.3969/j.issn.1674-8115.2016.06.027
%X 多囊卵巢综合征（PCOS）是一种常见的生殖系统疾病，影响着5%～10%育龄妇女的健康。尽管对其发病机制的研究不断深入，但其发病机制仍不明确。非编码RNA（ncRNA）指不翻译为蛋白的RNA，主要参与基因表达调控、表观遗传学调控等重要功能，近年来逐渐成为研究热点。研究发现多种ncRNA在PCOS患者的血清、卵泡液和颗粒细胞中表达量发生改变，并可能作为PCOS诊断的新靶点，这为PCOS发病机制的研究提供新思路。该文综述了近年来ncRNA在PCOS疾病发生发展中作用的研究进展。<br>： Polycystic ovary syndrome (PCOS) is a common reproductive system disease affecting approximately 5% to 10% of women of childbearing age. The pathogenesis of PCOS remains unclear despite increasing studies in recent years. ncRNAs are RNAs not translating into proteins and mainly involve in many important functions such as regulation of gene expression and epigenetics. ncRNAs become a research hotspot recently. Previous studies have found changes in expressions of various ncRNAs in serum, follicle fluid, and granulosa cells of PCOS patients. It may be a new target for the diagnose of PCOS and provide new idea for studying the pathogenesis of PCOS. This paper reviews recent research advances in the roles of ncRNA in the occurrence and development of PCOS
%K 多囊卵巢综合征
%K 非编码RNA
%K 微RNA
%K 长链非编码RNA
%K &lt
%K br&gt
%K polycystic ovary syndrome
%K ncRNA
%K microRNA
%K lncRNA
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11200.shtml